Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2V8N

Wild-type Structure of Lactose Permease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005351	molecular_function	carbohydrate:proton symporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0008643	biological_process	carbohydrate transport
A	0015212	molecular_function	cytidine transmembrane transporter activity
A	0015213	molecular_function	uridine transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015528	molecular_function	lactose:proton symporter activity
A	0015767	biological_process	lactose transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030395	molecular_function	lactose binding
A	0034219	biological_process	carbohydrate transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0071702	biological_process	organic substance transport
A	1902600	biological_process	proton transmembrane transport
B	0005351	molecular_function	carbohydrate:proton symporter activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0008643	biological_process	carbohydrate transport
B	0015212	molecular_function	cytidine transmembrane transporter activity
B	0015213	molecular_function	uridine transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015528	molecular_function	lactose:proton symporter activity
B	0015767	biological_process	lactose transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0030395	molecular_function	lactose binding
B	0034219	biological_process	carbohydrate transmembrane transport
B	0055085	biological_process	transmembrane transport
B	0071702	biological_process	organic substance transport
B	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00896
Number of Residues	15
Details	LACY_1 LacY family proton/sugar symporters signature 1. GLLsDKLGLRKyLLW

Chain	Residue	Details
A	GLY64-TRP78

site_id	PS00897
Number of Residues	15
Details	LACY_2 LacY family proton/sugar symporters signature 2. PlIINRIGgKNALLL

Chain	Residue	Details
A	PRO280-LEU294

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:2164211

Chain	Residue	Details
A	MET1-THR7
B	ALA187-PRO220
B	ALA279-GLY288
B	LYS335-SER346
A	GLY71-LYS74
A	GLU130-PHE140
A	ALA187-PRO220
A	ALA279-GLY288
A	LYS335-SER346
B	MET1-THR7
B	GLY71-LYS74
B	GLU130-PHE140

site_id	SWS_FT_FI2
Number of Residues	52
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ASN8-LEU34
B	ASN8-LEU34

site_id	SWS_FT_FI3
Number of Residues	36
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:2164211

Chain	Residue	Details
A	HIS35-SER41
B	PHE250-THR253
B	ALA309-SER311
B	SER375-GLY377
A	TYR101-LEU104
A	ILE164-ASN166
A	PHE250-THR253
A	ALA309-SER311
A	SER375-GLY377
B	HIS35-SER41
B	TYR101-LEU104
B	ILE164-ASN166

site_id	SWS_FT_FI4
Number of Residues	56
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	LYS42-LEU70
B	LYS42-LEU70

site_id	SWS_FT_FI5
Number of Residues	50
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	TYR75-GLN100
B	TYR75-GLN100

site_id	SWS_FT_FI6
Number of Residues	48
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	VAL105-ILE129
B	VAL105-ILE129

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLY141-THR163
B	GLY141-THR163

site_id	SWS_FT_FI8
Number of Residues	38
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	GLN167-PHE186
B	GLN167-PHE186

site_id	SWS_FT_FI9
Number of Residues	56
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LYS221-SER249
B	LYS221-SER249

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLY254-PHE278
B	GLY254-PHE278

site_id	SWS_FT_FI11
Number of Residues	38
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	LYS289-PHE308
B	LYS289-PHE308

site_id	SWS_FT_FI12
Number of Residues	44
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	ALA312-PHE334
B	ALA312-PHE334

site_id	SWS_FT_FI13
Number of Residues	54
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ALA347-GLU374
B	ALA347-GLU374

site_id	SWS_FT_FI14
Number of Residues	40
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	PHE378-PHE398
B	PHE378-PHE398

site_id	SWS_FT_FI15
Number of Residues	36
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996, ECO:0000269\|PubMed:2164211

Chain	Residue	Details
A	THR399-ALA417
B	THR399-ALA417

site_id	SWS_FT_FI16
Number of Residues	4
Details	SITE: Substrate binding => ECO:0000305\|PubMed:12893935

Chain	Residue	Details
A	GLU126
A	ARG144
B	GLU126
B	ARG144

site_id	SWS_FT_FI17
Number of Residues	2
Details	SITE: Substrate binding and proton translocation => ECO:0000305\|PubMed:12893935

Chain	Residue	Details
A	GLU269
B	GLU269

site_id	SWS_FT_FI18
Number of Residues	6
Details	SITE: Proton translocation => ECO:0000305\|PubMed:12893935

Chain	Residue	Details
A	ARG302
A	HIS322
A	GLU325
B	ARG302
B	HIS322
B	GLU325

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N-formylmethionine; partial => ECO:0000269\|PubMed:10485888

Chain	Residue	Details
A	MET1
B	MET1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)