2V8F

Mouse Profilin IIa in complex with a double repeat from the FH1 domain of mDia1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0003785	molecular_function	actin monomer binding
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0010633	biological_process	negative regulation of epithelial cell migration
A	0016887	molecular_function	ATP hydrolysis activity
A	0030036	biological_process	actin cytoskeleton organization
A	0030833	biological_process	regulation of actin filament polymerization
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0032233	biological_process	positive regulation of actin filament bundle assembly
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050821	biological_process	protein stabilization
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098885	biological_process	modification of postsynaptic actin cytoskeleton
A	0098978	cellular_component	glutamatergic synapse
A	0099140	biological_process	presynaptic actin cytoskeleton organization
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	1900028	biological_process	negative regulation of ruffle assembly
A	2000300	biological_process	regulation of synaptic vesicle exocytosis
B	0003779	molecular_function	actin binding
B	0003785	molecular_function	actin monomer binding
B	0005515	molecular_function	protein binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0010633	biological_process	negative regulation of epithelial cell migration
B	0016887	molecular_function	ATP hydrolysis activity
B	0030036	biological_process	actin cytoskeleton organization
B	0030833	biological_process	regulation of actin filament polymerization
B	0030838	biological_process	positive regulation of actin filament polymerization
B	0032233	biological_process	positive regulation of actin filament bundle assembly
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0050821	biological_process	protein stabilization
B	0051496	biological_process	positive regulation of stress fiber assembly
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098885	biological_process	modification of postsynaptic actin cytoskeleton
B	0098978	cellular_component	glutamatergic synapse
B	0099140	biological_process	presynaptic actin cytoskeleton organization
B	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
B	1900028	biological_process	negative regulation of ruffle assembly
B	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1140

Chain	Residue
A	ARG104
A	ARG135
A	HOH2150
A	HOH2151
B	LYS90
B	SER91

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1140

Chain	Residue
B	ARG104
B	ARG135
B	HOH2185

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL B 1141

Chain	Residue
A	TYR24
A	VAL51
A	GLY52
A	TYR78
A	HOH2033
B	SER91
B	GLY94
B	GLU95
B	HOH2129
B	HOH2186
B	HOH2187

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IPA B 1142

Chain	Residue
B	ASN9
B	MET130
B	HOH2170
C	LEU19

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1141

Chain	Residue
A	ARG74
A	ASP75
A	HOH2103

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1142

Chain	Residue
A	CYS25
A	ASP26
A	ALA27
A	ARG107
A	HOH2152
A	HOH2153
A	HOH2154
B	ARG88

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 1143

Chain	Residue
B	CYS25
B	ASP26
B	ALA27
B	TRP31
B	ARG107
B	HOH2147
B	HOH2188
B	HOH2189
C	PRO14

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 1144

Chain	Residue
A	HOH2049
B	GLN4
B	THR34
B	ALA35
B	HOH2006
B	HOH2190
B	HOH2191
B	HOH2192

---

Functional Information from PROSITE/UniProt

site_id	PS00414
Number of Residues	9
Details	PROFILIN Profilin signature. mAgWQsYvD

Chain	Residue	Details
A	MET0-ASP8

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P35080","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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