Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2V8F

Mouse Profilin IIa in complex with a double repeat from the FH1 domain of mDia1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0003785molecular_functionactin monomer binding
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0010633biological_processnegative regulation of epithelial cell migration
A0016887molecular_functionATP hydrolysis activity
A0030036biological_processactin cytoskeleton organization
A0030833biological_processregulation of actin filament polymerization
A0030837biological_processnegative regulation of actin filament polymerization
A0030838biological_processpositive regulation of actin filament polymerization
A0032233biological_processpositive regulation of actin filament bundle assembly
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0050804biological_processmodulation of chemical synaptic transmission
A0050821biological_processprotein stabilization
A0051496biological_processpositive regulation of stress fiber assembly
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098885biological_processmodification of postsynaptic actin cytoskeleton
A0098978cellular_componentglutamatergic synapse
A0099140biological_processpresynaptic actin cytoskeleton organization
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A1900028biological_processnegative regulation of ruffle assembly
A2000300biological_processregulation of synaptic vesicle exocytosis
B0003779molecular_functionactin binding
B0003785molecular_functionactin monomer binding
B0005515molecular_functionprotein binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0010633biological_processnegative regulation of epithelial cell migration
B0016887molecular_functionATP hydrolysis activity
B0030036biological_processactin cytoskeleton organization
B0030833biological_processregulation of actin filament polymerization
B0030837biological_processnegative regulation of actin filament polymerization
B0030838biological_processpositive regulation of actin filament polymerization
B0032233biological_processpositive regulation of actin filament bundle assembly
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0050804biological_processmodulation of chemical synaptic transmission
B0050821biological_processprotein stabilization
B0051496biological_processpositive regulation of stress fiber assembly
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098885biological_processmodification of postsynaptic actin cytoskeleton
B0098978cellular_componentglutamatergic synapse
B0099140biological_processpresynaptic actin cytoskeleton organization
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B1900028biological_processnegative regulation of ruffle assembly
B2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1140
ChainResidue
AARG104
AARG135
AHOH2150
AHOH2151
BLYS90
BSER91

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 1140
ChainResidue
BARG104
BARG135
BHOH2185

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GOL B 1141
ChainResidue
ATYR24
AVAL51
AGLY52
ATYR78
AHOH2033
BSER91
BGLY94
BGLU95
BHOH2129
BHOH2186
BHOH2187

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE IPA B 1142
ChainResidue
BASN9
BMET130
BHOH2170
CLEU19

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NA A 1141
ChainResidue
AARG74
AASP75
AHOH2103

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1142
ChainResidue
ACYS25
AASP26
AALA27
AARG107
AHOH2152
AHOH2153
AHOH2154
BARG88

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 B 1143
ChainResidue
BCYS25
BASP26
BALA27
BTRP31
BARG107
BHOH2147
BHOH2188
BHOH2189
CPRO14

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 1144
ChainResidue
AHOH2049
BGLN4
BTHR34
BALA35
BHOH2006
BHOH2190
BHOH2191
BHOH2192

Functional Information from PROSITE/UniProt
site_idPS00414
Number of Residues9
DetailsPROFILIN Profilin signature. mAgWQsYvD
ChainResidueDetails
AMET0-ASP8

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P35080
ChainResidueDetails
AALA1
BALA1

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon