Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2V7Q

The structure of F1-ATPase inhibited by I1-60HIS, a monomeric form of the inhibitor protein, IF1.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
D	0006754	biological_process	ATP biosynthetic process
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
E	0006754	biological_process	ATP biosynthetic process
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
F	0006754	biological_process	ATP biosynthetic process
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006754	biological_process	ATP biosynthetic process
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006754	biological_process	ATP biosynthetic process
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0032780	biological_process	negative regulation of ATP-dependent activity
J	0042030	molecular_function	ATPase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP A1511

Chain	Residue
A	ARG171
A	GLN432
A	MG1512
A	HOH2277
A	HOH2278
A	HOH2279
A	HOH2280
A	HOH2281
A	HOH2282
A	HOH2284
D	HOH2284
A	GLN172
D	HOH2285
A	THR173
A	GLY174
A	LYS175
A	THR176
A	SER177
A	PHE357
A	GLN430

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A1512

Chain	Residue
A	THR176
A	ATP1511
A	HOH2284
A	HOH2285
A	HOH2286

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ATP B1511

Chain	Residue
B	ARG171
B	GLN172
B	THR173
B	GLY174
B	LYS175
B	THR176
B	SER177
B	PHE357
B	GLN430
B	GLN432
B	MG1512
B	HOH2240
B	HOH2285
B	HOH2286
B	HOH2287
B	HOH2288
B	HOH2289
B	HOH2292
B	HOH2294
E	ARG356

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B1512

Chain	Residue
B	THR176
B	ATP1511
B	HOH2292
B	HOH2293
B	HOH2294

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ATP C1511

Chain	Residue
C	ARG171
C	GLN172
C	THR173
C	GLY174
C	LYS175
C	THR176
C	SER177
C	PHE357
C	ARG362
C	GLN430
C	GLN432
C	MG1512
C	HOH2136
C	HOH2284
C	HOH2285
C	HOH2286
C	HOH2287
C	HOH2288
C	HOH2294
C	HOH2296
F	TYR368
F	HOH2273

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C1512

Chain	Residue
C	THR176
C	ATP1511
C	HOH2294
C	HOH2295
C	HOH2296

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP D1478

Chain	Residue
D	GLY159
D	VAL160
D	GLY161
D	LYS162
D	THR163
D	VAL164
D	TYR345
D	PHE418
D	ALA421
D	PHE424
D	MG1479
D	HOH2141
D	HOH2326
D	HOH2362
D	HOH2363
D	HOH2366
D	HOH2367

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D1479

Chain	Residue
D	HOH2367
D	THR163
D	ADP1478
D	HOH2364
D	HOH2365
D	HOH2366

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 E1475

Chain	Residue
E	ALA158
E	GLY159
E	VAL160
E	GLY161
E	LYS162
E	THR163
E	HOH2216

site_id	BC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP F1475

Chain	Residue
B	ARG373
F	GLY159
F	VAL160
F	GLY161
F	LYS162
F	THR163
F	VAL164
F	TYR345
F	PHE418
F	ALA421
F	PHE424
F	THR425
F	MG1476
F	HOH2142
F	HOH2309
F	HOH2310
F	HOH2311
F	HOH2312
F	HOH2313
F	HOH2314
F	HOH2316

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F1476

Chain	Residue
F	THR163
F	ADP1475
F	HOH2313
F	HOH2314
F	HOH2315
F	HOH2316

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS

Chain	Residue	Details
D	PRO346-SER355
A	PRO363-SER372

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA

Chain	Residue	Details
G	ILE258-ALA271

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Participates in pH sensing

Chain	Residue	Details
J	GLU26
J	HIS49
I	THR37
B	GLN430
C	ASP170
C	GLN430

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P56382

Chain	Residue	Details
I	ILE44
G	LYS245
F	ARG189

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P36542

Chain	Residue	Details
G	LYS30
E	LYS472
F	LYS74
F	LYS111
F	LYS209
F	LYS214
F	LYS472
G	LYS172
D	LYS209
D	LYS214
D	LYS472
E	LYS74
E	LYS111
E	LYS209
E	LYS214

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q91VR2

Chain	Residue	Details
G	LYS90
C	SER22
C	SER123
C	SER141
G	LYS129
E	LYS148
E	LYS376
F	LYS148
F	LYS376
B	SER123
B	SER141
C	SER10

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P36542

Chain	Residue	Details
G	SER121
E	THR262
F	THR262

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P06576

Chain	Residue	Details
D	SER365
E	SER365
F	SER365

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P10719

Chain	Residue	Details
D	SER383
B	LYS498
C	LYS80
C	LYS83
C	LYS89
C	LYS197
C	LYS498
E	SER383
F	SER383
A	LYS197
A	LYS498
B	LYS80
B	LYS83
B	LYS89
B	LYS197

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P56480

Chain	Residue	Details
D	LYS430
D	LYS435
E	LYS430
E	LYS435
F	LYS430
F	LYS435

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER56
A	LYS488
A	LYS496
B	LYS118
B	LYS124
B	LYS187
B	LYS196
B	LYS218
B	LYS262
B	LYS384
B	LYS455
E	SER56
B	LYS463
B	LYS488
B	LYS496
C	LYS118
C	LYS124
C	LYS187
C	LYS196
C	LYS218
C	LYS262
C	LYS384
F	SER56
C	LYS455
C	LYS463
C	LYS488
C	LYS496
A	LYS196
A	LYS218
A	LYS262
A	LYS384
A	LYS455
A	LYS463

site_id	SWS_FT_FI10
Number of Residues	3
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:Q03265

Chain	Residue	Details
A	ARG161
B	ARG161
C	ARG161

site_id	SWS_FT_FI11
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P25705

Chain	Residue	Details
A	LYS391
B	LYS391
C	LYS391

site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250

Chain	Residue	Details
A	SER33
B	SER33
C	SER33

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
D	ARG356

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
E	ARG356

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
F	ARG356

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
C	ARG373
D	ARG189
D	GLU188
D	LYS162

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
A	ARG373
E	ARG189
E	GLU188
E	LYS162

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
F	ARG189
F	GLU188
F	LYS162
B	ARG373

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
A	LYS175
A	LYS209
A	GLN208

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
B	LYS175
B	LYS209
B	GLN208

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ohh

Chain	Residue	Details
C	LYS175
C	LYS209
C	GLN208

site_id	MCSA1
Number of Residues	3
Details	M-CSA 178

Chain	Residue	Details
D	LYS162	electrostatic stabiliser
D	GLU188	electrostatic stabiliser
D	ARG189	electrostatic stabiliser

site_id	MCSA2
Number of Residues	3
Details	M-CSA 178

Chain	Residue	Details
E	LYS162	electrostatic stabiliser
E	GLU188	electrostatic stabiliser
E	ARG189	electrostatic stabiliser

site_id	MCSA3
Number of Residues	3
Details	M-CSA 178

Chain	Residue	Details
F	LYS162	electrostatic stabiliser
F	GLU188	electrostatic stabiliser
F	ARG189	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)