2V5P

COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005537	molecular_function	D-mannose binding
A	0007041	biological_process	lysosomal transport
A	0038023	molecular_function	signaling receptor activity
B	0005537	molecular_function	D-mannose binding
B	0007041	biological_process	lysosomal transport
B	0038023	molecular_function	signaling receptor activity
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0008083	molecular_function	growth factor activity
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00023
Number of Residues	40
Details	FN2_1 Fibronectin type-II collagen-binding domain signature. CvfPFiFngksyeeCiiesrakl..WCsttaDYdrdheWgFC

Chain	Residue	Details
A	CYS1903-CYS1942

---

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlalLetyC

Chain	Residue	Details
C	CYS46-CYS60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	374
Details	Domain: {"description":"Fibronectin type-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00479","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	40
Details	Region: {"description":"A"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"28873464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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