2V50
The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005515 | molecular_function | protein binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015562 | molecular_function | efflux transmembrane transporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0022857 | molecular_function | transmembrane transporter activity |
| D | 0042908 | biological_process | xenobiotic transport |
| D | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| D | 0046677 | biological_process | response to antibiotic |
| D | 0055085 | biological_process | transmembrane transport |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0015562 | molecular_function | efflux transmembrane transporter activity |
| E | 0016020 | cellular_component | membrane |
| E | 0022857 | molecular_function | transmembrane transporter activity |
| E | 0042908 | biological_process | xenobiotic transport |
| E | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| E | 0046677 | biological_process | response to antibiotic |
| E | 0055085 | biological_process | transmembrane transport |
| F | 0005515 | molecular_function | protein binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0015562 | molecular_function | efflux transmembrane transporter activity |
| F | 0016020 | cellular_component | membrane |
| F | 0022857 | molecular_function | transmembrane transporter activity |
| F | 0042908 | biological_process | xenobiotic transport |
| F | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| F | 0046677 | biological_process | response to antibiotic |
| F | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LMT A 2026 |
| Chain | Residue |
| A | TRP13 |
| A | LEU17 |
| A | ARG363 |
| A | THR495 |
| A | LYS498 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LMT B 2031 |
| Chain | Residue |
| B | ILE472 |
| B | LEU867 |
| B | GLN871 |
| B | LMT2032 |
| B | PHE386 |
| B | ALA457 |
| B | PHE458 |
| B | ARG468 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LMT B 2032 |
| Chain | Residue |
| B | PHE458 |
| B | SER870 |
| B | GLN871 |
| B | LEU875 |
| B | LEU878 |
| B | LMT2031 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LMT D 2026 |
| Chain | Residue |
| D | TRP13 |
| D | LEU17 |
| D | ARG363 |
| D | THR495 |
| D | LYS498 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE LMT E 2031 |
| Chain | Residue |
| E | PHE386 |
| E | LEU454 |
| E | ALA457 |
| E | PHE458 |
| E | ARG468 |
| E | ILE472 |
| E | LMT2032 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMT E 2032 |
| Chain | Residue |
| D | LEU25 |
| D | LEU28 |
| E | LEU454 |
| E | PHE458 |
| E | SER870 |
| E | GLN871 |
| E | ALA874 |
| E | LEU875 |
| E | LEU878 |
| E | VAL882 |
| E | LMT2031 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMT E 2033 |
| Chain | Residue |
| E | GLN46 |
| E | VAL47 |
| E | SER48 |
| E | THR89 |
| E | GLN125 |
| E | GLY126 |
| E | GLY179 |
| E | SER180 |
| E | ARG620 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE LMT B 2033 |
| Chain | Residue |
| B | VAL47 |
| B | SER48 |
| B | GLN125 |
| B | GLY126 |
| B | VAL177 |
| B | GLY179 |
| B | SER180 |
| B | GLN273 |
| B | PHE615 |
| B | ASN616 |
| B | ARG620 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 780 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10187844 |
| Chain | Residue | Details |
| A | MET1-PRO9 | |
| B | GLU414-ALA441 | |
| B | LEU497-ARG538 | |
| B | GLU892-PRO897 | |
| B | GLU946-PRO972 | |
| B | SER1028-GLN1046 | |
| C | MET1-PRO9 | |
| C | GLN360-THR365 | |
| C | GLU414-ALA441 | |
| C | LEU497-ARG538 | |
| C | GLU892-PRO897 | |
| A | GLN360-THR365 | |
| C | GLU946-PRO972 | |
| C | SER1028-GLN1046 | |
| D | MET1-PRO9 | |
| D | GLN360-THR365 | |
| D | GLU414-ALA441 | |
| D | LEU497-ARG538 | |
| D | GLU892-PRO897 | |
| D | GLU946-PRO972 | |
| D | SER1028-GLN1046 | |
| E | MET1-PRO9 | |
| A | GLU414-ALA441 | |
| E | GLN360-THR365 | |
| E | GLU414-ALA441 | |
| E | LEU497-ARG538 | |
| E | GLU892-PRO897 | |
| E | GLU946-PRO972 | |
| E | SER1028-GLN1046 | |
| F | MET1-PRO9 | |
| F | GLN360-THR365 | |
| F | GLU414-ALA441 | |
| F | LEU497-ARG538 | |
| A | LEU497-ARG538 | |
| F | GLU892-PRO897 | |
| F | GLU946-PRO972 | |
| F | SER1028-GLN1046 | |
| A | GLU892-PRO897 | |
| A | GLU946-PRO972 | |
| A | SER1028-GLN1046 | |
| B | MET1-PRO9 | |
| B | GLN360-THR365 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1404 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ILE10-LEU28 | |
| A | VAL924-VAL945 | |
| A | ILE973-THR991 | |
| A | VAL1005-VAL1027 | |
| B | ILE10-LEU28 | |
| B | VAL340-LEU359 | |
| B | LEU366-ALA385 | |
| B | THR392-VAL413 | |
| B | LEU442-GLY460 | |
| B | ILE474-MET496 | |
| B | ALA539-THR557 | |
| A | VAL340-LEU359 | |
| B | ALA872-TYR891 | |
| B | PHE898-MET917 | |
| B | VAL924-VAL945 | |
| B | ILE973-THR991 | |
| B | VAL1005-VAL1027 | |
| C | ILE10-LEU28 | |
| C | VAL340-LEU359 | |
| C | LEU366-ALA385 | |
| C | THR392-VAL413 | |
| C | LEU442-GLY460 | |
| A | LEU366-ALA385 | |
| C | ILE474-MET496 | |
| C | ALA539-THR557 | |
| C | ALA872-TYR891 | |
| C | PHE898-MET917 | |
| C | VAL924-VAL945 | |
| C | ILE973-THR991 | |
| C | VAL1005-VAL1027 | |
| D | ILE10-LEU28 | |
| D | VAL340-LEU359 | |
| D | LEU366-ALA385 | |
| A | THR392-VAL413 | |
| D | THR392-VAL413 | |
| D | LEU442-GLY460 | |
| D | ILE474-MET496 | |
| D | ALA539-THR557 | |
| D | ALA872-TYR891 | |
| D | PHE898-MET917 | |
| D | VAL924-VAL945 | |
| D | ILE973-THR991 | |
| D | VAL1005-VAL1027 | |
| E | ILE10-LEU28 | |
| A | LEU442-GLY460 | |
| E | VAL340-LEU359 | |
| E | LEU366-ALA385 | |
| E | THR392-VAL413 | |
| E | LEU442-GLY460 | |
| E | ILE474-MET496 | |
| E | ALA539-THR557 | |
| E | ALA872-TYR891 | |
| E | PHE898-MET917 | |
| E | VAL924-VAL945 | |
| E | ILE973-THR991 | |
| A | ILE474-MET496 | |
| E | VAL1005-VAL1027 | |
| F | ILE10-LEU28 | |
| F | VAL340-LEU359 | |
| F | LEU366-ALA385 | |
| F | THR392-VAL413 | |
| F | LEU442-GLY460 | |
| F | ILE474-MET496 | |
| F | ALA539-THR557 | |
| F | ALA872-TYR891 | |
| F | PHE898-MET917 | |
| A | ALA539-THR557 | |
| F | VAL924-VAL945 | |
| F | ILE973-THR991 | |
| F | VAL1005-VAL1027 | |
| A | ALA872-TYR891 | |
| A | PHE898-MET917 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3942 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:10187844 |
| Chain | Residue | Details |
| A | SER29-GLU339 | |
| B | ARG558-GLN871 | |
| B | ARG918-ASP923 | |
| B | GLY992-GLY1004 | |
| C | SER29-GLU339 | |
| C | PHE386-ASN391 | |
| C | GLY461-THR473 | |
| C | ARG558-GLN871 | |
| C | ARG918-ASP923 | |
| C | GLY992-GLY1004 | |
| D | SER29-GLU339 | |
| A | PHE386-ASN391 | |
| D | PHE386-ASN391 | |
| D | GLY461-THR473 | |
| D | ARG558-GLN871 | |
| D | ARG918-ASP923 | |
| D | GLY992-GLY1004 | |
| E | SER29-GLU339 | |
| E | PHE386-ASN391 | |
| E | GLY461-THR473 | |
| E | ARG558-GLN871 | |
| E | ARG918-ASP923 | |
| A | GLY461-THR473 | |
| E | GLY992-GLY1004 | |
| F | SER29-GLU339 | |
| F | PHE386-ASN391 | |
| F | GLY461-THR473 | |
| F | ARG558-GLN871 | |
| F | ARG918-ASP923 | |
| F | GLY992-GLY1004 | |
| A | ARG558-GLN871 | |
| A | ARG918-ASP923 | |
| A | GLY992-GLY1004 | |
| B | SER29-GLU339 | |
| B | PHE386-ASN391 | |
| B | GLY461-THR473 |
