2V50

The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009636	biological_process	response to toxic substance
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009636	biological_process	response to toxic substance
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009636	biological_process	response to toxic substance
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0009636	biological_process	response to toxic substance
D	0015562	molecular_function	efflux transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0042908	biological_process	xenobiotic transport
D	0042910	molecular_function	xenobiotic transmembrane transporter activity
D	0046677	biological_process	response to antibiotic
D	0055085	biological_process	transmembrane transport
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0009636	biological_process	response to toxic substance
E	0015562	molecular_function	efflux transmembrane transporter activity
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0042908	biological_process	xenobiotic transport
E	0042910	molecular_function	xenobiotic transmembrane transporter activity
E	0046677	biological_process	response to antibiotic
E	0055085	biological_process	transmembrane transport
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0009636	biological_process	response to toxic substance
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0016020	cellular_component	membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0042908	biological_process	xenobiotic transport
F	0042910	molecular_function	xenobiotic transmembrane transporter activity
F	0046677	biological_process	response to antibiotic
F	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT A 2026

Chain	Residue
A	TRP13
A	LEU17
A	ARG363
A	THR495
A	LYS498

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LMT B 2031

Chain	Residue
B	ILE472
B	LEU867
B	GLN871
B	LMT2032
B	PHE386
B	ALA457
B	PHE458
B	ARG468

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LMT B 2032

Chain	Residue
B	PHE458
B	SER870
B	GLN871
B	LEU875
B	LEU878
B	LMT2031

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT D 2026

Chain	Residue
D	TRP13
D	LEU17
D	ARG363
D	THR495
D	LYS498

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LMT E 2031

Chain	Residue
E	PHE386
E	LEU454
E	ALA457
E	PHE458
E	ARG468
E	ILE472
E	LMT2032

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMT E 2032

Chain	Residue
D	LEU25
D	LEU28
E	LEU454
E	PHE458
E	SER870
E	GLN871
E	ALA874
E	LEU875
E	LEU878
E	VAL882
E	LMT2031

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LMT E 2033

Chain	Residue
E	GLN46
E	VAL47
E	SER48
E	THR89
E	GLN125
E	GLY126
E	GLY179
E	SER180
E	ARG620

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMT B 2033

Chain	Residue
B	VAL47
B	SER48
B	GLN125
B	GLY126
B	VAL177
B	GLY179
B	SER180
B	GLN273
B	PHE615
B	ASN616
B	ARG620

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1342
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2681
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"10187844","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	582
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10187844","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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