2V2J

Wild type recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0070288	cellular_component	ferritin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 1172

Chain	Residue
A	ASP80
A	ASP80
A	GLN82
A	GLN82

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 1002

Chain	Residue
A	ASP127
A	ASP127
A	ASP127

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 1173

Chain	Residue
A	GLU130
A	GLU130

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 1174

Chain	Residue
A	HIS114
A	CYS126
A	GLU130

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 1175

Chain	Residue
A	ASP38
A	CYS48
A	GOL1182

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 1176

Chain	Residue
A	GLU56
A	GLU57
A	GLU60
A	HOH2059

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 1177

Chain	Residue
A	GLU11

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 1178

Chain	Residue
A	GLU53
A	GLU56
A	HOH2058

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1179

Chain	Residue
A	ARG25
A	LYS83
A	SER85

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1180

Chain	Residue
A	ALA14
A	ASN17
A	ARG18
A	LEU77
A	HOH2016
A	HOH2071

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1181

Chain	Residue
A	SER32
A	PHE35
A	TYR36
A	ARG39
A	ASN70
A	GLY74
A	ARG75
A	ALA76
A	PHE78
A	HOH2139

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1182

Chain	Residue
A	PHE37
A	ASP38
A	ALA43
A	LEU44
A	GLU45
A	ASP146
A	CD1175
A	HOH2120
A	HOH2140

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1183

Chain	Residue
A	ASP127
A	SER131
A	HIS132
A	ASP135

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1184

Chain	Residue
A	GLN6
A	ASN7
A	HOH2141

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEshFLdeevklIK

Chain	Residue	Details
A	ASP122-LYS142

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgaERLLkmQNqRgGR

Chain	Residue	Details
A	GLU57-ARG75

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"Catalytic site for iron oxidation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---