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2V0Z

Crystal Structure of Renin with Inhibitor 10 (Aliskiren)

Functional Information from GO Data
ChainGOidnamespacecontents
C0004190molecular_functionaspartic-type endopeptidase activity
C0006508biological_processproteolysis
O0004190molecular_functionaspartic-type endopeptidase activity
O0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
ChainResidueDetails
CVAL29-VAL40
CALA212-GLY223

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:20927107
ChainResidueDetails
CASP32
CASP215
OASP32
OASP215

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
ChainResidueDetails
CASN-1
CASN67
OASN-1
OASN67

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
CASP215
CSER35
CALA218
CASP32

site_idCSA10
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
OASP215
OALA218
OASP32
OTHR33

site_idCSA11
Number of Residues2
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
CASP215
CASP32

site_idCSA12
Number of Residues2
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
OASP215
OASP32

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
OASP215
OSER35
OALA218
OASP32

site_idCSA3
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
CASP215
CTHR216
CASP32
CTHR33

site_idCSA4
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
OASP215
OTHR216
OASP32
OTHR33

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
CASP215
CSER35
CASP32

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
OASP215
OSER35
OASP32

site_idCSA7
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
CASP215
CTYR75
CSER35
CASP32

site_idCSA8
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
OASP215
OTYR75
OSER35
OASP32

site_idCSA9
Number of Residues4
DetailsAnnotated By Reference To The Literature 1am5
ChainResidueDetails
CASP215
CALA218
CASP32
CTHR33

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PDB entries from 2024-10-30

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