2V03
High resolution structure and catalysis of an O-acetylserine sulfhydrylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0019345 | biological_process | cysteine biosynthetic process via S-sulfo-L-cysteine |
| A | 0019450 | biological_process | L-cysteine catabolic process to pyruvate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP A 1041 |
| Chain | Residue |
| A | LYS41 |
| A | SER255 |
| A | CYS280 |
| A | ASP281 |
| A | TYR286 |
| A | CIT1297 |
| A | HOH2069 |
| A | HOH2070 |
| A | HOH2218 |
| A | HOH2329 |
| A | ASN71 |
| A | SER172 |
| A | GLY174 |
| A | THR175 |
| A | THR176 |
| A | GLY177 |
| A | THR178 |
| A | GLY208 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1295 |
| Chain | Residue |
| A | LEU31 |
| A | ASN34 |
| A | PRO36 |
| A | ILE250 |
| A | PHE251 |
| A | HOH2058 |
| A | HOH2065 |
| A | HOH2323 |
| A | HOH2324 |
| A | HOH2325 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1296 |
| Chain | Residue |
| A | GLU51 |
| A | GLU51 |
| A | LYS54 |
| A | LYS54 |
| A | ARG55 |
| A | ARG55 |
| A | ASP145 |
| A | ASP145 |
| A | HOH2326 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CIT A 1297 |
| Chain | Residue |
| A | LYS41 |
| A | THR68 |
| A | SER69 |
| A | GLY70 |
| A | ASN71 |
| A | THR72 |
| A | GLN140 |
| A | GLY174 |
| A | GLY208 |
| A | ARG210 |
| A | PLP1041 |
| A | HOH2327 |
| A | HOH2328 |
| A | HOH2329 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEgnn.PAgSVKdRaAlsM |
| Chain | Residue | Details |
| A | LYS30-MET48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15952768 |
| Chain | Residue | Details |
| A | ASN71 | |
| A | SER255 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY174 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS41 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| A | SER255 |
