2UZJ
Crystal structure of the mature streptococcal cysteine protease, mSpeB
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE E64 A 1254 |
| Chain | Residue |
| A | GLN17 |
| A | HOH2166 |
| B | GLN36 |
| B | SER37 |
| A | CYS47 |
| A | ASP130 |
| A | GLY136 |
| A | SER137 |
| A | GLY188 |
| A | GLY194 |
| A | HIS195 |
| A | HOH2165 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE E64 B 1254 |
| Chain | Residue |
| A | GLN36 |
| A | SER37 |
| B | GLN17 |
| B | CYS47 |
| B | VAL48 |
| B | ASP128 |
| B | ASP130 |
| B | SER135 |
| B | GLY136 |
| B | SER137 |
| B | ALA138 |
| B | GLN187 |
| B | GLY194 |
| B | HIS195 |
| B | HOH2018 |
| B | HOH2092 |
| B | HOH2099 |
| B | HOH2166 |
| B | HOH2167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P0C0J0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P0C0J0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D8E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D8E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0C0J0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Cysteine methyl disulfide; in zymogen form","evidences":[{"source":"UniProtKB","id":"P0C0J0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dki |
| Chain | Residue | Details |
| A | CYS47 | |
| A | HIS195 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dki |
| Chain | Residue | Details |
| B | CYS47 | |
| B | HIS195 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 598 |
| Chain | Residue | Details |
| A | CYS47 | |
| A | HIS195 | proton shuttle (general acid/base) |
| A | TRP212 |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 598 |
| Chain | Residue | Details |
| B | CYS47 | |
| B | HIS195 | proton shuttle (general acid/base) |
| B | TRP212 |
