2UZ9

Human guanine deaminase (guaD) in complex with zinc and its product Xanthine.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000255	biological_process	allantoin metabolic process
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006147	biological_process	guanine catabolic process
A	0006161	biological_process	deoxyguanosine catabolic process
A	0007399	biological_process	nervous system development
A	0008270	molecular_function	zinc ion binding
A	0008892	molecular_function	guanine deaminase activity
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0043605	biological_process	amide catabolic process
A	0046038	biological_process	GMP catabolic process
A	0046055	biological_process	dGMP catabolic process
A	0046098	biological_process	guanine metabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A1452

Chain	Residue
A	HIS82
A	HIS84
A	HIS240
A	ASP330
A	XAN1453

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE XAN A1453

Chain	Residue
A	LEU103
A	THR107
A	ARG213
A	PHE214
A	HIS240
A	GLU243
A	HIS279
A	ASP330
A	ZN1452
A	HOH2031
A	HIS84
A	GLN87
A	LEU99
A	TRP102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22662200, ECO:0007744|PDB:2UZ9

Chain	Residue	Details
A	HIS82
A	HIS84
A	HIS240
A	ASP330

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:22662200, ECO:0007744|PDB:2UZ9

Chain	Residue	Details
A	ARG213

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WTT6

Chain	Residue	Details
A	SER453

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