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2UYI

Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33

Functional Information from GO Data
ChainGOidnamespacecontents
A0003777molecular_functionmicrotubule motor activity
A0005524molecular_functionATP binding
A0007018biological_processmicrotubule-based movement
A0008017molecular_functionmicrotubule binding
B0003777molecular_functionmicrotubule motor activity
B0005524molecular_functionATP binding
B0007018biological_processmicrotubule-based movement
B0008017molecular_functionmicrotubule binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 603
ChainResidue
ATHR112
AADP601
AHOH2037
AHOH2081
AHOH2135
AHOH2136

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 603
ChainResidue
BHOH2096
BHOH2134
BHOH2136
BTHR112
BADP601
BHOH2084

site_idAC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ADP A 601
ChainResidue
AARG24
AARG26
APRO27
AGLN106
ATHR107
AGLY108
ATHR109
AGLY110
ALYS111
ATHR112
APHE113
AGLU118
AMG603
AHOH2008
AHOH2037
AHOH2134
AHOH2135
AHOH2136
AHOH2137
AHOH2138

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE K02 A 604
ChainResidue
AGLU116
AGLU118
AARG119
ATRP127
AASP130
AALA133
APRO137
ALEU214
AGLU215
AGLY217
AALA218
AARG221
AHOH2039

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ADP B 601
ChainResidue
BARG24
BARG26
BPRO27
BGLN106
BGLY108
BTHR109
BGLY110
BLYS111
BTHR112
BPHE113
BGLU118
BMG603
BHOH2096
BHOH2133
BHOH2134
BHOH2136
BHOH2137
BHOH2138

site_idAC6
Number of Residues12
DetailsBINDING SITE FOR RESIDUE K02 B 604
ChainResidue
BGLU116
BGLU118
BARG119
BTRP127
BALA133
BPRO137
BTYR211
BLEU214
BGLU215
BGLY217
BALA218
BARG221

Functional Information from PROSITE/UniProt
site_idPS00411
Number of Residues12
DetailsKINESIN_MOTOR_1 Kinesin motor domain signature. GKLnLVDLAGSE
ChainResidueDetails
AGLY259-GLU270

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00283
ChainResidueDetails
AGLY105
BGLY105

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS146
BLYS146

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1goj
ChainResidueDetails
AGLY268

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1goj
ChainResidueDetails
BGLY268

226707

PDB entries from 2024-10-30

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