2UYG
Crystallogaphic structure of the typeII 3-Dehydroquinase from Thermus Thermophilus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019631 | biological_process | quinate catabolic process |
| B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019631 | biological_process | quinate catabolic process |
| C | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019631 | biological_process | quinate catabolic process |
| D | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019631 | biological_process | quinate catabolic process |
| E | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0009423 | biological_process | chorismate biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019631 | biological_process | quinate catabolic process |
| F | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0009423 | biological_process | chorismate biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019631 | biological_process | quinate catabolic process |
| G | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0009423 | biological_process | chorismate biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019631 | biological_process | quinate catabolic process |
| H | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0009423 | biological_process | chorismate biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0019631 | biological_process | quinate catabolic process |
| I | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| I | 0008652 | biological_process | amino acid biosynthetic process |
| I | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| I | 0009423 | biological_process | chorismate biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0019631 | biological_process | quinate catabolic process |
| J | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| J | 0008652 | biological_process | amino acid biosynthetic process |
| J | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| J | 0009423 | biological_process | chorismate biosynthetic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0019631 | biological_process | quinate catabolic process |
| K | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| K | 0008652 | biological_process | amino acid biosynthetic process |
| K | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| K | 0009423 | biological_process | chorismate biosynthetic process |
| K | 0016829 | molecular_function | lyase activity |
| K | 0019631 | biological_process | quinate catabolic process |
| L | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| L | 0008652 | biological_process | amino acid biosynthetic process |
| L | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| L | 0009423 | biological_process | chorismate biosynthetic process |
| L | 0016829 | molecular_function | lyase activity |
| L | 0019631 | biological_process | quinate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A1143 |
| Chain | Residue |
| A | LEU10 |
| A | ARG16 |
| A | HIS79 |
| A | HIS99 |
| A | LEU100 |
| A | LEU103 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B1143 |
| Chain | Residue |
| B | LEU100 |
| B | HOH2018 |
| B | ARG16 |
| B | TYR21 |
| B | HIS99 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C1143 |
| Chain | Residue |
| C | ARG16 |
| C | TYR21 |
| C | HIS79 |
| C | HIS99 |
| C | LEU100 |
| C | LEU103 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D1143 |
| Chain | Residue |
| D | ARG16 |
| D | TYR21 |
| D | HIS99 |
| D | LEU100 |
| D | THR101 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E1143 |
| Chain | Residue |
| E | ARG16 |
| E | TYR21 |
| E | ASN73 |
| E | HIS99 |
| E | LEU100 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL F1143 |
| Chain | Residue |
| F | LEU10 |
| F | ARG16 |
| F | TYR21 |
| F | HIS79 |
| F | HIS99 |
| F | LEU103 |
| F | ARG110 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL G1143 |
| Chain | Residue |
| G | ARG16 |
| G | TYR21 |
| G | ASN73 |
| G | HIS99 |
| G | LEU100 |
| G | LEU103 |
| G | HOH2007 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL H1143 |
| Chain | Residue |
| H | LEU10 |
| H | ARG16 |
| H | TYR21 |
| H | ASN73 |
| H | HIS99 |
| H | LEU100 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL I1143 |
| Chain | Residue |
| I | ARG16 |
| I | ASN73 |
| I | HIS79 |
| I | HIS99 |
| I | LEU100 |
| I | LEU103 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL J1143 |
| Chain | Residue |
| J | ARG16 |
| J | TYR21 |
| J | HIS79 |
| J | HIS99 |
| J | LEU100 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL K1143 |
| Chain | Residue |
| K | ARG16 |
| K | TYR21 |
| K | HIS79 |
| K | HIS99 |
| K | LEU100 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL L1143 |
| Chain | Residue |
| L | ARG16 |
| L | TYR21 |
| L | HIS79 |
| L | HIS99 |
| L | LEU100 |
| L | LEU103 |
| L | ARG110 |
Functional Information from PROSITE/UniProt
| site_id | PS01029 |
| Number of Residues | 18 |
| Details | DEHYDROQUINASE_II Dehydroquinase class II signature. LNGPNLnlLGrREpevYG |
| Chain | Residue | Details |
| A | LEU5-GLY22 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | TYR21 | |
| J | TYR21 | |
| K | TYR21 | |
| L | TYR21 | |
| B | TYR21 | |
| C | TYR21 | |
| D | TYR21 | |
| E | TYR21 | |
| F | TYR21 | |
| G | TYR21 | |
| H | TYR21 | |
| I | TYR21 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | HIS99 | |
| J | HIS99 | |
| K | HIS99 | |
| L | HIS99 | |
| B | HIS99 | |
| C | HIS99 | |
| D | HIS99 | |
| E | HIS99 | |
| F | HIS99 | |
| G | HIS99 | |
| H | HIS99 | |
| I | HIS99 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | ASN73 | |
| B | ARG110 | |
| C | ASN73 | |
| C | HIS79 | |
| C | ASP86 | |
| C | LEU100 | |
| C | ARG110 | |
| D | ASN73 | |
| D | HIS79 | |
| D | ASP86 | |
| D | LEU100 | |
| A | HIS79 | |
| D | ARG110 | |
| E | ASN73 | |
| E | HIS79 | |
| E | ASP86 | |
| E | LEU100 | |
| E | ARG110 | |
| F | ASN73 | |
| F | HIS79 | |
| F | ASP86 | |
| F | LEU100 | |
| A | ASP86 | |
| F | ARG110 | |
| G | ASN73 | |
| G | HIS79 | |
| G | ASP86 | |
| G | LEU100 | |
| G | ARG110 | |
| H | ASN73 | |
| H | HIS79 | |
| H | ASP86 | |
| H | LEU100 | |
| A | LEU100 | |
| H | ARG110 | |
| I | ASN73 | |
| I | HIS79 | |
| I | ASP86 | |
| I | LEU100 | |
| I | ARG110 | |
| J | ASN73 | |
| J | HIS79 | |
| J | ASP86 | |
| J | LEU100 | |
| A | ARG110 | |
| J | ARG110 | |
| K | ASN73 | |
| K | HIS79 | |
| K | ASP86 | |
| K | LEU100 | |
| K | ARG110 | |
| L | ASN73 | |
| L | HIS79 | |
| L | ASP86 | |
| L | LEU100 | |
| B | ASN73 | |
| L | ARG110 | |
| B | HIS79 | |
| B | ASP86 | |
| B | LEU100 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | ARG16 | |
| J | ARG16 | |
| K | ARG16 | |
| L | ARG16 | |
| B | ARG16 | |
| C | ARG16 | |
| D | ARG16 | |
| E | ARG16 | |
| F | ARG16 | |
| G | ARG16 | |
| H | ARG16 | |
| I | ARG16 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| A | GLU97 | |
| A | ARG106 | |
| A | TYR21 | |
| A | ARG16 | |
| A | HIS99 | |
| A | ASN9 |
| site_id | CSA10 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| J | GLU97 | |
| J | ARG106 | |
| J | TYR21 | |
| J | ARG16 | |
| J | HIS99 | |
| J | ASN9 |
| site_id | CSA11 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| K | GLU97 | |
| K | ARG106 | |
| K | TYR21 | |
| K | ARG16 | |
| K | HIS99 | |
| K | ASN9 |
| site_id | CSA12 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| L | GLU97 | |
| L | ARG106 | |
| L | TYR21 | |
| L | ARG16 | |
| L | HIS99 | |
| L | ASN9 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| B | GLU97 | |
| B | ARG106 | |
| B | TYR21 | |
| B | ARG16 | |
| B | HIS99 | |
| B | ASN9 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| C | GLU97 | |
| C | ARG106 | |
| C | TYR21 | |
| C | ARG16 | |
| C | HIS99 | |
| C | ASN9 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| D | GLU97 | |
| D | ARG106 | |
| D | TYR21 | |
| D | ARG16 | |
| D | HIS99 | |
| D | ASN9 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| E | GLU97 | |
| E | ARG106 | |
| E | TYR21 | |
| E | ARG16 | |
| E | HIS99 | |
| E | ASN9 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| F | GLU97 | |
| F | ARG106 | |
| F | TYR21 | |
| F | ARG16 | |
| F | HIS99 | |
| F | ASN9 |
| site_id | CSA7 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| G | GLU97 | |
| G | ARG106 | |
| G | TYR21 | |
| G | ARG16 | |
| G | HIS99 | |
| G | ASN9 |
| site_id | CSA8 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| H | GLU97 | |
| H | ARG106 | |
| H | TYR21 | |
| H | ARG16 | |
| H | HIS99 | |
| H | ASN9 |
| site_id | CSA9 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| I | GLU97 | |
| I | ARG106 | |
| I | TYR21 | |
| I | ARG16 | |
| I | HIS99 | |
| I | ASN9 |
