Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2TCL

STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 170

Chain	Residue
A	HIS118
A	HIS122
A	HIS128
A	RO4175

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SM A 171

Chain	Residue
A	HOH218
A	ASP24
A	GLU99
A	GLU101
A	HOH195
A	HOH217

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 172

Chain	Residue
A	HIS68
A	ASP70
A	HIS83
A	HIS96

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 173

Chain	Residue
A	ASP75
A	GLY76
A	GLY78
A	ASN80
A	ASP98
A	GLU101

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 174

Chain	Residue
A	ASP58
A	GLY90
A	GLY92
A	ASP94
A	HOH201
A	HOH240

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE RO4 A 175

Chain	Residue
A	GLY79
A	ASN80
A	LEU81
A	ALA82
A	PHE107
A	TYR110
A	HIS118
A	GLU119
A	HIS122
A	HIS128
A	PRO138
A	SER139
A	TYR140
A	ZN170
A	HOH176
A	HOH177

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL

Chain	Residue	Details
A	VAL115-LEU124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000105","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	MET136
A	GLU119

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1hfs

Chain	Residue	Details
A	GLU119

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)