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2TCI

X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL

Replaces:  1TCI
Functional Information from GO Data
ChainGOidnamespacecontents
A0005179molecular_functionhormone activity
A0005576cellular_componentextracellular region
B0005179molecular_functionhormone activity
B0005576cellular_componentextracellular region
C0005179molecular_functionhormone activity
C0005576cellular_componentextracellular region
D0005179molecular_functionhormone activity
D0005576cellular_componentextracellular region
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SCN B 200
ChainResidue
BHIS10
BHIS10
BHIS10
BZN201
BZN201
BZN201

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN B 201
ChainResidue
BSCN200
BSCN200
BSCN200
BHIS10
BHIS10
BHIS10

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ZN D 31
ChainResidue
DHIS10
DHIS10
DHIS10
DHOH32
DHOH32
DHOH32
DHOH34
DHOH34
DHOH34

Functional Information from PROSITE/UniProt
site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCTSiCSlyqLenyC
ChainResidueDetails
ACYS6-CYS20

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PDB entries from 2024-11-06

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