2ROZ

Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of APP Reveals a Novel Peptide Binding Mode

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
B	0001540	molecular_function	amyloid-beta binding

Functional Information from PROSITE/UniProt

site_id	PS00320
Number of Residues	8
Details	APP_INTRA Amyloid precursor protein (APP) intracellular domain signature. GYENPTYK

Chain	Residue	Details
A	GLY18-LYS25

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Region: {"description":"Required for the interaction with KIF5B and for anterograde transport in axons","evidences":[{"source":"UniProtKB","id":"P05067","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"YENPXY motif; contains endocytosis signal","evidences":[{"source":"UniProtKB","id":"P05067","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage; by a caspase","evidences":[{"source":"UniProtKB","id":"P05067","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CDK5 and MAPK10 and LRRK2","evidences":[{"source":"PubMed","id":"28720718","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"11279131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P08592","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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