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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2RKA

The Structure of rat cytosolic PEPCK in complex with phosphoglycolate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0004550molecular_functionnucleoside diphosphate kinase activity
A0004611molecular_functionphosphoenolpyruvate carboxykinase activity
A0004613molecular_functionphosphoenolpyruvate carboxykinase (GTP) activity
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006094biological_processgluconeogenesis
A0006107biological_processoxaloacetate metabolic process
A0006629biological_processlipid metabolic process
A0009617biological_processresponse to bacterium
A0014823biological_processresponse to activity
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0016829molecular_functionlyase activity
A0016831molecular_functioncarboxy-lyase activity
A0017076molecular_functionpurine nucleotide binding
A0018105biological_processpeptidyl-serine phosphorylation
A0019003molecular_functionGDP binding
A0030145molecular_functionmanganese ion binding
A0031406molecular_functioncarboxylic acid binding
A0031667biological_processresponse to nutrient levels
A0032496biological_processresponse to lipopolysaccharide
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0033993biological_processresponse to lipid
A0042593biological_processglucose homeostasis
A0042594biological_processresponse to starvation
A0043382biological_processpositive regulation of memory T cell differentiation
A0043648biological_processdicarboxylic acid metabolic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046166biological_processglyceraldehyde-3-phosphate biosynthetic process
A0046327biological_processglycerol biosynthetic process from pyruvate
A0046872molecular_functionmetal ion binding
A0046889biological_processpositive regulation of lipid biosynthetic process
A0046890biological_processregulation of lipid biosynthetic process
A0051365biological_processcellular response to potassium ion starvation
A0070365biological_processhepatocyte differentiation
A0070741biological_processresponse to interleukin-6
A0071300biological_processcellular response to retinoic acid
A0071320biological_processcellular response to cAMP
A0071332biological_processcellular response to fructose stimulus
A0071333biological_processcellular response to glucose stimulus
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071377biological_processcellular response to glucagon stimulus
A0071456biological_processcellular response to hypoxia
A0071474biological_processcellular hyperosmotic response
A0071475biological_processcellular hyperosmotic salinity response
A0071476biological_processcellular hypotonic response
A0071477biological_processcellular hypotonic salinity response
A0071549biological_processcellular response to dexamethasone stimulus
A0072350biological_processtricarboxylic acid metabolic process
A0097403biological_processcellular response to raffinose
A0106264molecular_functionprotein serine kinase activity (using GTP as donor)
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
A1904640biological_processresponse to methionine
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0004550molecular_functionnucleoside diphosphate kinase activity
C0004611molecular_functionphosphoenolpyruvate carboxykinase activity
C0004613molecular_functionphosphoenolpyruvate carboxykinase (GTP) activity
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006094biological_processgluconeogenesis
C0006107biological_processoxaloacetate metabolic process
C0006629biological_processlipid metabolic process
C0009617biological_processresponse to bacterium
C0014823biological_processresponse to activity
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0016829molecular_functionlyase activity
C0016831molecular_functioncarboxy-lyase activity
C0017076molecular_functionpurine nucleotide binding
C0018105biological_processpeptidyl-serine phosphorylation
C0019003molecular_functionGDP binding
C0030145molecular_functionmanganese ion binding
C0031406molecular_functioncarboxylic acid binding
C0031667biological_processresponse to nutrient levels
C0032496biological_processresponse to lipopolysaccharide
C0032868biological_processresponse to insulin
C0032869biological_processcellular response to insulin stimulus
C0033993biological_processresponse to lipid
C0042593biological_processglucose homeostasis
C0042594biological_processresponse to starvation
C0043382biological_processpositive regulation of memory T cell differentiation
C0043648biological_processdicarboxylic acid metabolic process
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046166biological_processglyceraldehyde-3-phosphate biosynthetic process
C0046327biological_processglycerol biosynthetic process from pyruvate
C0046872molecular_functionmetal ion binding
C0046889biological_processpositive regulation of lipid biosynthetic process
C0046890biological_processregulation of lipid biosynthetic process
C0051365biological_processcellular response to potassium ion starvation
C0070365biological_processhepatocyte differentiation
C0070741biological_processresponse to interleukin-6
C0071300biological_processcellular response to retinoic acid
C0071320biological_processcellular response to cAMP
C0071332biological_processcellular response to fructose stimulus
C0071333biological_processcellular response to glucose stimulus
C0071347biological_processcellular response to interleukin-1
C0071356biological_processcellular response to tumor necrosis factor
C0071377biological_processcellular response to glucagon stimulus
C0071456biological_processcellular response to hypoxia
C0071474biological_processcellular hyperosmotic response
C0071475biological_processcellular hyperosmotic salinity response
C0071476biological_processcellular hypotonic response
C0071477biological_processcellular hypotonic salinity response
C0071549biological_processcellular response to dexamethasone stimulus
C0072350biological_processtricarboxylic acid metabolic process
C0097403biological_processcellular response to raffinose
C0106264molecular_functionprotein serine kinase activity (using GTP as donor)
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C1904640biological_processresponse to methionine
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PGA A 623
ChainResidue
AARG87
AMN700
AHOH703
AHOH1099
AHOH1138
AGLY236
AGLY237
ALYS243
ALYS244
AASP311
APHE333
AASN403
AARG405
site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE PGA C 623
ChainResidue
CALA86
CARG87
CTYR235
CGLY236
CGLY237
CLYS243
CLYS244
CASP311
CPHE333
CASN403
CARG405
CPHE485
CMN700
CHOH704
CHOH705
CHOH987
CHOH1114
site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN A 700
ChainResidue
ALYS244
AHIS264
AASP311
APGA623
AHOH703
AHOH704
AHOH1138
site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 701
ChainResidue
AHIS502
AGLU607
AHOH753
AHOH1016
AHOH1017
site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA A 702
ChainResidue
ALEU79
AASN208
AHOH815
AHOH914
AHOH1021
site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN C 700
ChainResidue
CLYS244
CHIS264
CASP311
CPGA623
CHOH703
CHOH704
CHOH1114
site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN C 701
ChainResidue
CHIS502
CGLU607
CHOH1007
site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA C 702
ChainResidue
CLEU79
CASN208
CHOH779
CHOH791
Functional Information from PROSITE/UniProt
site_idPS00505
Number of Residues9
DetailsPEPCK_GTP Phosphoenolpyruvate carboxykinase (GTP) signature. FPSACGKTN
ChainResidueDetails
APHE284-ASN292
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2909519","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31461616","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P5O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
AHIS264
ALYS290
AARG405
site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
CHIS264
CLYS290
CARG405
site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
AHIS264
AARG405
site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1aq2
ChainResidueDetails
CHIS264
CARG405

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PDB entries from 2026-01-14

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