2RJ3
Crystal Structure of the Uridine Phosphorylase from Salmonella Typhimurium in Complex with Uracil and Phosphate Ion at 2.49A Resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 7001 |
| Chain | Residue |
| A | GLY1026 |
| A | ARG1030 |
| A | ARG1091 |
| A | ILE1092 |
| A | GLY1093 |
| A | THR1094 |
| A | GLU1198 |
| F | ARG4048 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 C 7002 |
| Chain | Residue |
| C | ARG2091 |
| C | GLY2093 |
| C | THR2094 |
| C | GLU2198 |
| C | GLY2026 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 7003 |
| Chain | Residue |
| B | ARG6048 |
| D | GLY3026 |
| D | ARG3030 |
| D | ARG3091 |
| D | ILE3092 |
| D | GLY3093 |
| D | THR3094 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 F 7004 |
| Chain | Residue |
| A | ARG1048 |
| F | GLY4026 |
| F | ARG4091 |
| F | ILE4092 |
| F | GLY4093 |
| F | THR4094 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 E 7005 |
| Chain | Residue |
| C | ARG2048 |
| E | GLY5026 |
| E | ARG5030 |
| E | ARG5091 |
| E | GLY5093 |
| E | THR5094 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 7006 |
| Chain | Residue |
| B | GLY6026 |
| B | ARG6091 |
| B | ILE6092 |
| B | GLY6093 |
| B | THR6094 |
| D | ARG3048 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE URA A 8001 |
| Chain | Residue |
| A | THR1094 |
| A | THR1095 |
| A | GLY1096 |
| A | GLN1166 |
| A | ARG1168 |
| A | TYR1195 |
| A | GLU1196 |
| A | MET1197 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE URA D 8003 |
| Chain | Residue |
| D | THR3094 |
| D | THR3095 |
| D | GLY3096 |
| D | PHE3162 |
| D | GLN3166 |
| D | ARG3168 |
| D | GLU3196 |
| D | MET3197 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE URA F 8004 |
| Chain | Residue |
| F | THR4094 |
| F | THR4095 |
| F | PHE4162 |
| F | GLN4166 |
| F | ARG4168 |
| F | GLU4196 |
| F | MET4197 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE URA E 8005 |
| Chain | Residue |
| E | THR5095 |
| E | GLY5096 |
| E | GLN5166 |
| E | ARG5168 |
| E | TYR5195 |
| E | GLU5196 |
| E | MET5197 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE URA B 8006 |
| Chain | Residue |
| B | THR6094 |
| B | THR6095 |
| B | GLY6096 |
| B | PHE6162 |
| B | GLN6166 |
| B | ARG6168 |
| B | GLU6196 |
| B | MET6197 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER1066-LEU1081 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| A | ARG1223 | |
| A | GLU1080 | |
| A | HIS1008 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| C | ARG2223 | |
| C | GLU2080 | |
| C | HIS2008 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| D | GLU3080 | |
| D | HIS3008 | |
| D | ARG3223 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| F | HIS4008 | |
| F | GLU4080 | |
| F | ARG4223 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| E | GLU5080 | |
| E | ARG5223 | |
| E | HIS5008 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| B | HIS6008 | |
| B | GLU6080 | |
| B | ARG6223 |
