2RHS
PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| A | 0043039 | biological_process | tRNA aminoacylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| B | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0140096 | molecular_function | catalytic activity, acting on a protein |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| C | 0043039 | biological_process | tRNA aminoacylation |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| D | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| D | 0016740 | molecular_function | transferase activity |
| D | 0140096 | molecular_function | catalytic activity, acting on a protein |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 801 |
| Chain | Residue |
| B | LYS731 |
| B | HIS735 |
| B | SER744 |
| B | THR745 |
| B | HOH1060 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 3 |
| Chain | Residue |
| C | CYS267 |
| C | CYS270 |
| C | CYS275 |
| C | CYS278 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 801 |
| Chain | Residue |
| D | LYS731 |
| D | HIS735 |
| D | SER744 |
| D | THR745 |
| D | HOH952 |
| D | HOH1071 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GAX A 1 |
| Chain | Residue |
| A | SER174 |
| A | GLN177 |
| A | GLN214 |
| A | GLU216 |
| A | PHE254 |
| A | PRO255 |
| A | PHE256 |
| A | THR257 |
| A | GLY288 |
| A | ALA289 |
| A | VAL296 |
| A | ALA311 |
| A | GLY313 |
| A | HOH391 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GAX C 2 |
| Chain | Residue |
| C | SER174 |
| C | GLN177 |
| C | MET181 |
| C | GLN214 |
| C | GLU216 |
| C | PHE254 |
| C | PHE256 |
| C | THR257 |
| C | GLY288 |
| C | ALA289 |
| C | VAL296 |
| C | ALA311 |
| C | GLY313 |
| C | HOH418 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00281","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 150 |
| Details | Domain: {"description":"B5","evidences":[{"source":"HAMAP-Rule","id":"MF_00283","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00283","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b7y |
| Chain | Residue | Details |
| A | ALA311 | |
| A | ARG200 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b7y |
| Chain | Residue | Details |
| C | ALA311 | |
| C | ARG200 |
