2RHS

PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004826	molecular_function	phenylalanine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006432	biological_process	phenylalanyl-tRNA aminoacylation
A	0043039	biological_process	tRNA aminoacylation
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003723	molecular_function	RNA binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004826	molecular_function	phenylalanine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006412	biological_process	translation
B	0006432	biological_process	phenylalanyl-tRNA aminoacylation
B	0009328	cellular_component	phenylalanine-tRNA ligase complex
B	0016740	molecular_function	transferase activity
B	0016874	molecular_function	ligase activity
B	0046872	molecular_function	metal ion binding
B	0140096	molecular_function	catalytic activity, acting on a protein
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004826	molecular_function	phenylalanine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006432	biological_process	phenylalanyl-tRNA aminoacylation
C	0043039	biological_process	tRNA aminoacylation
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003723	molecular_function	RNA binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004826	molecular_function	phenylalanine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006412	biological_process	translation
D	0006432	biological_process	phenylalanyl-tRNA aminoacylation
D	0009328	cellular_component	phenylalanine-tRNA ligase complex
D	0016740	molecular_function	transferase activity
D	0016874	molecular_function	ligase activity
D	0046872	molecular_function	metal ion binding
D	0140096	molecular_function	catalytic activity, acting on a protein

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 801

Chain	Residue
B	LYS731
B	HIS735
B	SER744
B	THR745
B	HOH1060

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 3

Chain	Residue
C	CYS267
C	CYS270
C	CYS275
C	CYS278

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 801

Chain	Residue
D	LYS731
D	HIS735
D	SER744
D	THR745
D	HOH952
D	HOH1071

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GAX A 1

Chain	Residue
A	SER174
A	GLN177
A	GLN214
A	GLU216
A	PHE254
A	PRO255
A	PHE256
A	THR257
A	GLY288
A	ALA289
A	VAL296
A	ALA311
A	GLY313
A	HOH391

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GAX C 2

Chain	Residue
C	SER174
C	GLN177
C	MET181
C	GLN214
C	GLU216
C	PHE254
C	PHE256
C	THR257
C	GLY288
C	ALA289
C	VAL296
C	ALA311
C	GLY313
C	HOH418

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00281","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	150
Details	Domain: {"description":"B5","evidences":[{"source":"HAMAP-Rule","id":"MF_00283","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00283","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1b7y

Chain	Residue	Details
A	ALA311
A	ARG200

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1b7y

Chain	Residue	Details
C	ALA311
C	ARG200

---