2REN

STRUCTURE OF RECOMBINANT HUMAN RENIN, A TARGET FOR CARDIOVASCULAR-ACTIVE DRUGS, AT 2.5 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV

Chain	Residue	Details
A	VAL35-VAL46
A	ALA223-GLY234

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:20927107

Chain	Residue	Details
A	ASP38
A	ASP226

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678

Chain	Residue	Details
A	ASN5
A	ASN75

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1avf

Chain	Residue	Details
A	ASP38

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1avf

Chain	Residue	Details
A	ASP226

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1avf

Chain	Residue	Details
A	ASP38
A	ASP226
A	THR39
A	THR227

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site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1avf

Chain	Residue	Details
A	ASP38
A	ASP226
A	SER41

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site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1avf

Chain	Residue	Details
A	ASP38
A	ASP226
A	TYR83
A	SER41

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