Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2RC3

Crystal structure of CBS domain, NE2398

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
B	0000166	molecular_function	nucleotide binding
C	0000166	molecular_function	nucleotide binding
D	0000166	molecular_function	nucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR B 171

Chain	Residue
B	ARG76
B	ARG124
B	HIS125
C	HOH1001

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR C 171

Chain	Residue
B	HOH1013
C	THR74
C	ARG76
C	ARG124

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BR A 171

Chain	Residue
A	ARG76
A	ARG124
A	BR174
D	HOH1017
A	THR74

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR D 171

Chain	Residue
A	HOH1005
D	ARG76
D	ARG124
D	HOH1016

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR D 172

Chain	Residue
D	ARG100

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B 172

Chain	Residue
B	ARG100
B	GLN101

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR B 173

Chain	Residue
B	PRO42

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR C 173

Chain	Residue
C	PRO42
C	ASP43

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR D 173

Chain	Residue
D	ARG100
D	GLN101
D	HOH1113

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR C 174

Chain	Residue
C	ARG100
C	GLN101
C	BR183
D	GLY132

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR D 174

Chain	Residue
B	HOH1182
D	LYS68
D	HOH1033

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 172

Chain	Residue
A	PRO42

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR D 175

Chain	Residue
A	LYS24
A	THR25
A	HIS28
D	LYS87

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR D 176

Chain	Residue
D	GLU96

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 173

Chain	Residue
A	ALA39
A	LYS52

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR D 177

Chain	Residue
D	ALA39
D	LYS52

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 176

Chain	Residue
C	ARG100

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR D 178

Chain	Residue
D	GLY41
D	PRO42
D	ASP43

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BR A 174

Chain	Residue
A	ARG124
A	BR171
A	HOH1001
A	HOH1056
A	HOH1144

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR C 177

Chain	Residue
C	ALA39
C	LYS52

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR D 179

Chain	Residue
D	THR25
D	HIS28

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR C 178

Chain	Residue
C	HOH1078
D	THR25

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR B 174

Chain	Residue
B	GLU32

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR D 180

Chain	Residue
B	PRO42
B	ASP43
D	GLU67
D	HOH1126

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR A 175

Chain	Residue
A	GLY41
A	PRO42
A	ASP43
A	HOH1106

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 179

Chain	Residue
C	GLN93

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 176

Chain	Residue
A	SER45

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR D 182

Chain	Residue
D	ASP106
D	LEU107
D	ASP130
D	HOH1083

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 180

Chain	Residue
C	SER45

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BR A 177

Chain	Residue
A	ARG100
A	GLN101
A	HOH1038
B	GLY132
B	HOH1095

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR C 181

Chain	Residue
C	ASN108

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR C 182

Chain	Residue
C	ASP131
C	GLY132
C	HOH1102

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR D 183

Chain	Residue
D	THR74
D	HOH1016
D	HOH1086
D	HOH1098

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR B 175

Chain	Residue
B	VAL37

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR C 183

Chain	Residue
C	ARG100
C	BR174
C	HOH1103

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 178

Chain	Residue
A	HIS35

site_id	EC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD D 1000

Chain	Residue
A	HOH1082
B	ASP113
D	LYS33
D	THR36
D	VAL38
D	ILE58
D	GLY59
D	ALA60
D	LEU62
D	HIS125
D	LEU137
D	SER139
D	ILE140
D	GLY141
D	ASP142
D	LYS145
D	HOH1007
D	HOH1009
D	HOH1028
D	HOH1144
A	ARG76
A	ILE118
A	THR119
A	ARG122
A	VAL123
A	ARG124
A	ILE140

site_id	EC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAD C 1000

Chain	Residue
B	ARG76
B	ILE118
B	THR119
B	ARG122
B	VAL123
B	ARG124
B	ILE140
C	LYS33
C	THR36
C	VAL37
C	VAL38
C	ILE58
C	GLY59
C	ALA60
C	LEU62
C	HIS125
C	LEU137
C	SER139
C	ILE140
C	GLY141
C	ASP142
C	LYS145
C	HOH1004
C	HOH1010
C	HOH1048
C	HOH1095
C	HOH1096
C	HOH1155
C	HOH1162

site_id	EC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD B 1000

Chain	Residue
B	LYS33
B	THR36
B	VAL38
B	ILE58
B	GLY59
B	ALA60
B	LEU62
B	HIS125
B	LEU137
B	SER139
B	ILE140
B	GLY141
B	ASP142
B	LYS145
B	HOH1004
B	HOH1005
B	HOH1062
B	HOH1094
C	ARG76
C	ILE118
C	THR119
C	ARG122
C	VAL123
C	ARG124
C	ILE140
C	HOH1086
D	ASP113

site_id	EC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD A 1000

Chain	Residue
A	LYS33
A	THR36
A	VAL38
A	ILE58
A	GLY59
A	ALA60
A	LEU62
A	HIS125
A	LEU137
A	SER139
A	ILE140
A	GLY141
A	ASP142
A	LYS145
A	HOH1010
A	HOH1037
A	HOH1135
A	HOH1171
D	ARG76
D	ILE118
D	THR119
D	ARG122
D	VAL123
D	ARG124
D	ILE140

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)