2R4V
Structure of human CLIC2, crystal form A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034707 | cellular_component | chloride channel complex |
| A | 0060315 | biological_process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GSH A 248 |
| Chain | Residue |
| A | GLU25 |
| A | SER26 |
| A | ILE27 |
| A | PHE37 |
| A | TRP41 |
| A | THR51 |
| A | HIS227 |
| A | HOH330 |
| A | HOH347 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GSH A 249 |
| Chain | Residue |
| A | PRO97 |
| A | ARG98 |
| A | TYR99 |
| A | PRO100 |
| A | HIS101 |
| A | ALA131 |
| A | ASN134 |
| A | PHE135 |
| A | GLN178 |
| A | HOH328 |
| A | HOH372 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Note=After insertion into the membrane","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 163 |
| Details | Domain: {"description":"GST C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00685","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Region: {"description":"Joint loop"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Region: {"description":"Foot loop"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Motif: {"description":"G-site","evidences":[{"source":"PubMed","id":"25581026","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17945253","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R4V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
