2R37
Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0006982 | biological_process | response to lipid hydroperoxide |
| A | 0008430 | molecular_function | selenium binding |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0006982 | biological_process | response to lipid hydroperoxide |
| B | 0008430 | molecular_function | selenium binding |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | GLY73 |
| A | GLY74 |
| A | LEU75 |
| A | TRP181 |
| A | ASN182 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 2 |
| Chain | Residue |
| B | ASN182 |
| B | GLY73 |
| B | GLY74 |
| B | LEU75 |
| B | TRP181 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 237 |
| Chain | Residue |
| A | SER166 |
| A | LEU169 |
| A | HOH300 |
| A | HOH412 |
| A | HOH413 |
| A | HOH417 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 237 |
| Chain | Residue |
| B | SER166 |
| B | LEU169 |
| B | HOH257 |
| B | HOH381 |
| B | HOH382 |
| B | HOH411 |
Functional Information from PROSITE/UniProt
| site_id | PS00763 |
| Number of Residues | 8 |
| Details | GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LGFPCNQF |
| Chain | Residue | Details |
| A | LEU97-PHE104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLY73 | |
| B | GLY73 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gp1 |
| Chain | Residue | Details |
| A | TRP181 | |
| A | GLN107 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gp1 |
| Chain | Residue | Details |
| B | TRP181 | |
| B | GLN107 |
