2R2I

Myristoylated Guanylate Cyclase Activating Protein-1 with Calcium Bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001750	cellular_component	photoreceptor outer segment
A	0001917	cellular_component	photoreceptor inner segment
A	0005509	molecular_function	calcium ion binding
A	0007601	biological_process	visual perception
A	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
A	0009966	biological_process	regulation of signal transduction
A	0030249	molecular_function	guanylate cyclase regulator activity
A	0031284	biological_process	positive regulation of guanylate cyclase activity
A	0046872	molecular_function	metal ion binding
A	0071277	biological_process	cellular response to calcium ion
A	0120199	cellular_component	cone photoreceptor outer segment

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 500

Chain	Residue
A	ASP63
A	ASN65
A	ASP67
A	TYR69
A	GLU74
A	HOH505

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	CYS105
A	GLU110
A	HOH567
A	ASP99
A	ASP101
A	ASN103

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP142
A	ASN144
A	ASP146
A	GLU148
A	GLU153
A	HOH512

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MYR A 1

Chain	Residue
A	GLY2
A	ASN3
A	MET4
A	PHE42
A	LEU44
A	ALA78
A	VAL178
A	HOH560

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 300

Chain	Residue
A	ASP5
A	ALA8
A	CYS17
A	VAL76
A	LEU79
A	SER80

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME A 301

Chain	Residue
A	GLU27
A	CYS28
A	GLN32
A	LEU33
A	GLU37

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 302

Chain	Residue
A	GLY104
A	CYS105
A	GLU148
A	SER150

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 303

Chain	Residue
A	CYS124
A	MET128
A	PHE133
A	MET136
A	VAL163
A	ILE167

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DFNKDGYIDfmEY

Chain	Residue	Details
A	ASP63-TYR75
A	ASP99-LEU111
A	ASP142-PHE154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	35
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17997965","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Deamidated asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"17997965","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---