2R26
The Structure of the Ternary Complex of Carboxymethyl Coenzyme A and Oxalateacetate with Citrate Synthase from the Thermophilic Archaeonthermoplasma Acidophilum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004108 | molecular_function | citrate (Si)-synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016740 | molecular_function | transferase activity |
| A | 0036440 | molecular_function | citrate synthase activity |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0004108 | molecular_function | citrate (Si)-synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016740 | molecular_function | transferase activity |
| B | 0036440 | molecular_function | citrate synthase activity |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0004108 | molecular_function | citrate (Si)-synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016740 | molecular_function | transferase activity |
| C | 0036440 | molecular_function | citrate synthase activity |
| C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| D | 0004108 | molecular_function | citrate (Si)-synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016740 | molecular_function | transferase activity |
| D | 0036440 | molecular_function | citrate synthase activity |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OAA B 500 |
| Chain | Residue |
| A | ARG364 |
| B | HOH705 |
| B | HIS187 |
| B | PRO190 |
| B | HIS222 |
| B | HIS262 |
| B | ARG271 |
| B | PHE340 |
| B | ARG344 |
| B | HOH703 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OAA A 501 |
| Chain | Residue |
| A | HIS187 |
| A | PRO190 |
| A | HIS222 |
| A | HIS262 |
| A | ARG271 |
| A | PHE340 |
| A | ARG344 |
| A | HOH782 |
| B | ARG364 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OAA C 502 |
| Chain | Residue |
| C | HIS187 |
| C | PRO190 |
| C | HIS222 |
| C | HIS262 |
| C | ARG271 |
| C | PHE340 |
| C | ARG344 |
| C | HOH715 |
| C | HOH756 |
| D | ARG364 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OAA D 503 |
| Chain | Residue |
| C | ARG364 |
| D | HIS187 |
| D | PRO190 |
| D | HIS222 |
| D | HIS262 |
| D | ARG271 |
| D | PHE340 |
| D | ARG344 |
| D | HOH714 |
| D | HOH751 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE CMC B 700 |
| Chain | Residue |
| A | ARG361 |
| B | LEU221 |
| B | HIS222 |
| B | GLY223 |
| B | ALA225 |
| B | ARG256 |
| B | LEU257 |
| B | GLY259 |
| B | PHE260 |
| B | GLY261 |
| B | HIS262 |
| B | ARG263 |
| B | ILE312 |
| B | ASN315 |
| B | ASP317 |
| B | PHE340 |
| B | HOH706 |
| B | HOH714 |
| B | HOH756 |
| B | HOH765 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE CMC A 701 |
| Chain | Residue |
| A | LEU221 |
| A | HIS222 |
| A | GLY223 |
| A | ALA225 |
| A | ARG256 |
| A | LEU257 |
| A | GLY259 |
| A | PHE260 |
| A | GLY261 |
| A | HIS262 |
| A | ARG263 |
| A | ASN315 |
| A | ASP317 |
| A | PHE340 |
| A | HOH839 |
| A | HOH852 |
| A | HOH854 |
| A | HOH936 |
| A | HOH941 |
| B | ARG361 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE CMC C 702 |
| Chain | Residue |
| C | LEU221 |
| C | HIS222 |
| C | ALA225 |
| C | ARG256 |
| C | LEU257 |
| C | MET258 |
| C | GLY259 |
| C | PHE260 |
| C | GLY261 |
| C | HIS262 |
| C | ARG263 |
| C | ILE312 |
| C | ASN315 |
| C | ASP317 |
| C | HOH784 |
| C | HOH810 |
| C | HOH834 |
| C | HOH849 |
| C | HOH884 |
| D | ARG361 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE CMC D 703 |
| Chain | Residue |
| B | LYS151 |
| C | ARG361 |
| D | LEU221 |
| D | HIS222 |
| D | GLY223 |
| D | ALA225 |
| D | ARG256 |
| D | LEU257 |
| D | GLY259 |
| D | PHE260 |
| D | GLY261 |
| D | HIS262 |
| D | ARG263 |
| D | LYS310 |
| D | ILE312 |
| D | ASN315 |
| D | ASP317 |
| D | PHE340 |
| D | HOH740 |
| D | HOH777 |
| D | HOH799 |
| D | HOH818 |
| D | HOH945 |
Functional Information from PROSITE/UniProt
| site_id | PS00480 |
| Number of Residues | 13 |
| Details | CITRATE_SYNTHASE Citrate synthase signature. GFGHrVy.KtyDPR |
| Chain | Residue | Details |
| A | GLY259-ARG271 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:7704526 |
| Chain | Residue | Details |
| A | HIS222 | |
| D | HIS222 | |
| D | HIS262 | |
| D | ASP317 | |
| A | HIS262 | |
| A | ASP317 | |
| B | HIS222 | |
| B | HIS262 | |
| B | ASP317 | |
| C | HIS222 | |
| C | HIS262 | |
| C | ASP317 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | ASP317 | |
| A | HIS262 | |
| A | HIS222 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | ASP317 | |
| B | HIS262 | |
| B | HIS222 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| C | ASP317 | |
| C | HIS262 | |
| C | HIS222 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| D | ASP317 | |
| D | HIS262 | |
| D | HIS222 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | SER192 | |
| A | HIS262 | |
| A | ASP317 | |
| A | HIS222 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | SER192 | |
| B | HIS262 | |
| B | ASP317 | |
| B | HIS222 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| C | SER192 | |
| C | HIS262 | |
| C | ASP317 | |
| C | HIS222 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| D | SER192 | |
| D | HIS262 | |
| D | ASP317 | |
| D | HIS222 |
