2R00

crystal structure of aspartate semialdehyde dehydrogenase II complexed with ASA from vibrio cholerae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
A	0006520	biological_process	amino acid metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009085	biological_process	lysine biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009097	biological_process	isoleucine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0046983	molecular_function	protein dimerization activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
B	0006520	biological_process	amino acid metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009085	biological_process	lysine biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0009097	biological_process	isoleucine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0046983	molecular_function	protein dimerization activity
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
C	0006520	biological_process	amino acid metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009085	biological_process	lysine biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009097	biological_process	isoleucine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0046983	molecular_function	protein dimerization activity
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0071266	biological_process	'de novo' L-methionine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE OEG C 1

Chain	Residue
C	VAL17
C	HOH536
C	HOH537
C	HOH539
C	HOH565
C	ASN97
C	ARG102
C	HTI133
C	SER163
C	ASN317
C	VAL318
C	ALA322
C	HOH535

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Functional Information from PROSITE/UniProt

site_id	PS01103
Number of Residues	15
Details	ASD Aspartate-semialdehyde dehydrogenase signature. VNptCvRVpvfyGHA

Chain	Residue	Details
C	VAL233-ALA247
A	VAL233-ALA247

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000269|PubMed:18323627

Chain	Residue	Details
C	HTI133
B	CYS133

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_02121

Chain	Residue	Details
C	HIS246
B	HIS246

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02121

Chain	Residue	Details
C	THR14
B	ARG42
B	ARG102
B	GLN160
B	SER163
B	LYS217
B	ARG239
B	ASN317
C	ARG42
C	ARG102
C	GLN160
C	SER163
C	LYS217
C	ARG239
C	ASN317
B	THR14

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1brm

Chain	Residue	Details
A	CYS133
A	HIS246
A	GLN160

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1brm

Chain	Residue	Details
B	CYS133
B	HIS246
B	GLN160

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1brm

Chain	Residue	Details
C	HIS246
C	GLN160

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1brm

Chain	Residue	Details
A	CYS133
A	GLN160

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site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1brm

Chain	Residue	Details
B	CYS133
B	GLN160

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