Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 161 |
| Chain | Residue |
| A | ASP96 |
| A | ASP98 |
| A | MG162 |
| A | APC171 |
| A | HOH182 |
| A | HOH184 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 162 |
| Chain | Residue |
| A | APC171 |
| A | PH2181 |
| A | HOH183 |
| A | ASP96 |
| A | ASP98 |
| A | MG161 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 163 |
| Chain | Residue |
| B | ASP96 |
| B | ASP98 |
| B | MG164 |
| B | APC172 |
| B | HOH185 |
| B | HOH186 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 164 |
| Chain | Residue |
| B | ASP96 |
| B | ASP98 |
| B | MG163 |
| B | APC172 |
| B | PH2182 |
| B | HOH187 |
| site_id | AC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE APC A 171 |
| Chain | Residue |
| A | GLN75 |
| A | ARG93 |
| A | ASP96 |
| A | ASP98 |
| A | ILE99 |
| A | ARG111 |
| A | THR113 |
| A | ILE114 |
| A | HIS116 |
| A | TYR117 |
| A | ARG122 |
| A | MG161 |
| A | MG162 |
| A | PH2181 |
| A | HOH182 |
| A | HOH184 |
| A | HOH185 |
| A | HOH186 |
| A | HOH188 |
| A | HOH195 |
| A | HOH196 |
| A | HOH197 |
| A | HOH209 |
| A | HOH210 |
| A | HOH226 |
| A | HOH316 |
| B | ARG89 |
| B | TYR117 |
| B | APC172 |
| B | HOH193 |
| site_id | AC6 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE APC B 172 |
| Chain | Residue |
| A | ARG89 |
| A | TYR117 |
| A | APC171 |
| A | HOH195 |
| A | HOH196 |
| A | HOH213 |
| B | LEU71 |
| B | GLN75 |
| B | ARG93 |
| B | ASP96 |
| B | ASP98 |
| B | ILE99 |
| B | ARG111 |
| B | THR113 |
| B | ILE114 |
| B | HIS116 |
| B | TYR117 |
| B | ARG122 |
| B | MG163 |
| B | MG164 |
| B | PH2182 |
| B | HOH185 |
| B | HOH186 |
| B | HOH190 |
| B | HOH193 |
| B | HOH199 |
| B | HOH201 |
| B | HOH202 |
| B | HOH217 |
| B | HOH307 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PH2 A 181 |
| Chain | Residue |
| A | THR43 |
| A | LYS44 |
| A | PRO45 |
| A | LEU46 |
| A | PHE54 |
| A | ASN56 |
| A | ASP96 |
| A | PHE124 |
| A | MG162 |
| A | APC171 |
| A | HOH183 |
| A | HOH189 |
| A | HOH222 |
| A | HOH316 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PH2 B 182 |
| Chain | Residue |
| B | LYS44 |
| B | PRO45 |
| B | LEU46 |
| B | PHE54 |
| B | ASN56 |
| B | ASP96 |
| B | PHE124 |
| B | MG164 |
| B | APC172 |
| B | HOH187 |
| B | HOH194 |
| B | HOH212 |
| B | THR43 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG89-MET100 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG83 | |
| A | ARG93 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | ARG83 | |
| B | ARG93 | |
