2QTS
Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0015280 | molecular_function | ligand-gated sodium channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0015280 | molecular_function | ligand-gated sodium channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0005272 | molecular_function | sodium channel activity |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0015280 | molecular_function | ligand-gated sodium channel activity |
| D | 0016020 | cellular_component | membrane |
| E | 0005272 | molecular_function | sodium channel activity |
| E | 0006814 | biological_process | sodium ion transport |
| E | 0015280 | molecular_function | ligand-gated sodium channel activity |
| E | 0016020 | cellular_component | membrane |
| F | 0005272 | molecular_function | sodium channel activity |
| F | 0006814 | biological_process | sodium ion transport |
| F | 0015280 | molecular_function | ligand-gated sodium channel activity |
| F | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR304-CYS324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 126 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2112 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 145 |
| Details | Transmembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Motif: {"description":"GAS motif; ion selectivity filter","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Site: {"description":"Involved in proton-dependent gating","evidences":[{"source":"UniProtKB","id":"P78348","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17882215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22760635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QTS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
