2QRE

Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranotide (ZMP)

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006110	biological_process	regulation of glycolytic process
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0007165	biological_process	signal transduction
E	0010514	biological_process	induction of conjugation with cellular fusion
E	0016208	molecular_function	AMP binding
E	0019887	molecular_function	protein kinase regulator activity
E	0019901	molecular_function	protein kinase binding
E	0030295	molecular_function	protein kinase activator activity
E	0031588	cellular_component	nucleotide-activated protein kinase complex
E	0042149	biological_process	cellular response to glucose starvation
E	0043531	molecular_function	ADP binding
E	0043609	biological_process	regulation of carbon utilization
E	0045722	biological_process	positive regulation of gluconeogenesis
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006110	biological_process	regulation of glycolytic process
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0007165	biological_process	signal transduction
G	0010514	biological_process	induction of conjugation with cellular fusion
G	0016208	molecular_function	AMP binding
G	0019887	molecular_function	protein kinase regulator activity
G	0019901	molecular_function	protein kinase binding
G	0030295	molecular_function	protein kinase activator activity
G	0031588	cellular_component	nucleotide-activated protein kinase complex
G	0042149	biological_process	cellular response to glucose starvation
G	0043531	molecular_function	ADP binding
G	0043609	biological_process	regulation of carbon utilization
G	0045722	biological_process	positive regulation of gluconeogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMZ G 1001

Chain	Residue
G	ARG139
G	SER305
G	ASP308
G	ARG141
G	THR191
G	LEU195
G	ALA196
G	LYS214
G	ILE216
G	SER217
G	ILE303

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMZ E 1002

Chain	Residue
E	ARG139
E	ARG141
E	THR191
E	LEU195
E	ALA196
E	ASN215
E	ILE216
E	SER217
E	ILE303
E	SER305
E	ASP308

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"2QR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QRC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QRD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	Domain: {"description":"CBS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	124
Details	Domain: {"description":"CBS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	120
Details	Domain: {"description":"CBS 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17937917","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QR1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17289942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17937917","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OOY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17289942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OOY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17289942","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OOX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---