Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004797 | molecular_function | thymidine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046104 | biological_process | thymidine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071897 | biological_process | DNA biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004797 | molecular_function | thymidine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046104 | biological_process | thymidine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | CYS140 |
| A | CYS143 |
| A | CYS173 |
| A | CYS176 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 402 |
| Chain | Residue |
| B | CYS140 |
| B | CYS143 |
| B | CYS173 |
| B | CYS176 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 450 |
| Chain | Residue |
| A | ANP601 |
| A | HOH616 |
| A | HOH617 |
| A | HOH749 |
| A | THR17 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 452 |
| Chain | Residue |
| B | THR17 |
| B | TMP601 |
| B | ADP701 |
| B | HOH725 |
| B | HOH797 |
| B | HOH844 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE THM A 501 |
| Chain | Residue |
| A | GLU84 |
| A | GLN86 |
| A | PHE87 |
| A | LEU111 |
| A | THR114 |
| A | HIS115 |
| A | THR151 |
| A | GLU160 |
| A | ILE161 |
| A | ASP162 |
| A | VAL163 |
| A | GLY164 |
| A | TYR169 |
| A | ANP601 |
| A | HOH675 |
| A | HOH767 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE TMP B 601 |
| Chain | Residue |
| B | MET12 |
| B | LYS16 |
| B | HIS53 |
| B | GLU84 |
| B | GLN86 |
| B | PHE87 |
| B | LEU111 |
| B | THR114 |
| B | HIS115 |
| B | THR151 |
| B | GLU160 |
| B | ILE161 |
| B | ASP162 |
| B | VAL163 |
| B | GLY164 |
| B | TYR169 |
| B | MG452 |
| B | ADP701 |
| B | HOH717 |
| B | HOH725 |
| B | HOH774 |
| B | HOH797 |
| B | HOH798 |
| B | HOH844 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ANP A 601 |
| Chain | Residue |
| A | MET12 |
| A | TYR13 |
| A | SER14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | THR18 |
| A | SER52 |
| A | HIS53 |
| A | GLU84 |
| A | ALA138 |
| A | VAL139 |
| A | GLN166 |
| A | MG450 |
| A | THM501 |
| A | HOH617 |
| A | HOH640 |
| A | HOH643 |
| A | HOH675 |
| A | HOH708 |
| A | HOH749 |
| B | GLU25 |
| B | LEU29 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP B 701 |
| Chain | Residue |
| B | HOH843 |
| B | HOH844 |
| B | HOH882 |
| A | GLU25 |
| A | LEU29 |
| B | TYR13 |
| B | SER14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| B | THR18 |
| B | SER52 |
| B | HIS53 |
| B | ALA138 |
| B | VAL139 |
| B | MG452 |
| B | TMP601 |
| B | HOH725 |
| B | HOH811 |
| B | HOH828 |
Functional Information from PROSITE/UniProt
| site_id | PS00603 |
| Number of Residues | 14 |
| Details | TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GgqEkYiAvCRdCY |
| Chain | Residue | Details |
| A | GLY164-TYR177 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
