2QOG
Crotoxin B, the basic PLA2 from Crotalus durissus terrificus.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| B | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0044398 | biological_process | venom-mediated edema |
| B | 0044478 | biological_process | venom-mediated platelet aggregation |
| B | 0044521 | biological_process | venom-mediated muscle damage in another organism |
| B | 0044522 | biological_process | venom-mediated myocyte killing in another organism |
| B | 0050482 | biological_process | arachidonate secretion |
| C | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006644 | biological_process | phospholipid metabolic process |
| C | 0016042 | biological_process | lipid catabolic process |
| C | 0042130 | biological_process | negative regulation of T cell proliferation |
| C | 0044398 | biological_process | venom-mediated edema |
| C | 0044478 | biological_process | venom-mediated platelet aggregation |
| C | 0044521 | biological_process | venom-mediated muscle damage in another organism |
| C | 0044522 | biological_process | venom-mediated myocyte killing in another organism |
| C | 0050482 | biological_process | arachidonate secretion |
| D | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005543 | molecular_function | phospholipid binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006644 | biological_process | phospholipid metabolic process |
| D | 0016042 | biological_process | lipid catabolic process |
| D | 0042130 | biological_process | negative regulation of T cell proliferation |
| D | 0050482 | biological_process | arachidonate secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 134 |
| Chain | Residue |
| B | TYR28 |
| B | GLY30 |
| B | GLY32 |
| B | ASP49 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 134 |
| Chain | Residue |
| C | TYR28 |
| C | GLY30 |
| C | GLY32 |
| C | ASP49 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Responsible for the weak stability and toxicity","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | Site: {"description":"Putative interfacial binding surface (IBS)","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Responsible for the reduced anticoagulant activity (compared with CBc)","evidences":[{"source":"PubMed","id":"18062812","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"18275084","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18275084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QOG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Responsible for the higher anticoagulant activity (compared with CBa2)","evidences":[{"source":"PubMed","id":"18062812","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS48 | |
| A | GLY30 | |
| A | ASP99 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| D | HIS48 | |
| D | GLY30 | |
| D | ASP99 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| B | HIS48 | |
| B | GLY30 | |
| B | ASP99 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| C | HIS48 | |
| C | GLY30 | |
| C | ASP99 |
