2QO3

Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSisVDtACSSSlvAL

Chain	Residue	Details
A	GLY193-LEU209

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Acyl-thioester intermediate; for beta-ketoacyl synthase 1 activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:17719492

Chain	Residue	Details
A	CYS202
B	CYS202

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For beta-ketoacyl synthase 1 activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	HIS337
A	HIS377
B	HIS337
B	HIS377

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: Acyl-ester intermediate; for acyltransferase 1 activity => ECO:0000255|PROSITE-ProRule:PRU10022

Chain	Residue	Details
A	SER651
B	SER651

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Important for substrate specificity of the beta-ketoacyl synthase 1 => ECO:0000305|PubMed:17719492

Chain	Residue	Details
A	LYS155
A	PHE156
B	LYS155
B	PHE156

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