2QMU

Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0003723	molecular_function	RNA binding
B	0003743	molecular_function	translation initiation factor activity
C	0003743	molecular_function	translation initiation factor activity
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 414

Chain	Residue
C	CYS106
C	CYS109
C	CYS127
C	CYS130

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 416

Chain	Residue
A	HIS37
A	LYS48
A	HOH418

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site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP A 417

Chain	Residue
A	GLY21
A	LYS22
A	THR23
A	THR24
A	LYS36
A	HIS37
A	ASN149
A	LYS150
A	ASP152
A	SER184
A	ALA185
A	LEU186
C	LYS117
A	ASP19
A	HIS20

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:4RD1

Chain	Residue	Details
A	ASP19
A	GLY44

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:16407071, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:2AHO

Chain	Residue	Details
A	THR23
A	THR46

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q8U082, ECO:0000255|HAMAP-Rule:MF_00119

Chain	Residue	Details
A	CYS59
A	CYS62
A	CYS74
A	CYS77

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:4RCY, ECO:0007744|PDB:4RD1

Chain	Residue	Details
A	ASN149
A	SER184

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ASP19

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	HIS97

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