2QMR
Karyopherin beta2/transportin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005929 | cellular_component | cilium |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0015031 | biological_process | protein transport |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031981 | cellular_component | nuclear lumen |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005929 | cellular_component | cilium |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0008139 | molecular_function | nuclear localization sequence binding |
| B | 0015031 | biological_process | protein transport |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0031981 | cellular_component | nuclear lumen |
| B | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005929 | cellular_component | cilium |
| C | 0006606 | biological_process | protein import into nucleus |
| C | 0006886 | biological_process | intracellular protein transport |
| C | 0008139 | molecular_function | nuclear localization sequence binding |
| C | 0015031 | biological_process | protein transport |
| C | 0031267 | molecular_function | small GTPase binding |
| C | 0031981 | cellular_component | nuclear lumen |
| C | 0061608 | molecular_function | nuclear import signal receptor activity |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005730 | cellular_component | nucleolus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005929 | cellular_component | cilium |
| D | 0006606 | biological_process | protein import into nucleus |
| D | 0006886 | biological_process | intracellular protein transport |
| D | 0008139 | molecular_function | nuclear localization sequence binding |
| D | 0015031 | biological_process | protein transport |
| D | 0031267 | molecular_function | small GTPase binding |
| D | 0031981 | cellular_component | nuclear lumen |
| D | 0061608 | molecular_function | nuclear import signal receptor activity |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Repeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 272 |
| Details | Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 152 |
| Details | Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 74 |
| Details | Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 120 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 108 |
| Details | Repeat: {"description":"HEAT 6","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 108 |
| Details | Repeat: {"description":"HEAT 7","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 112 |
| Details | Repeat: {"description":"HEAT 9","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 108 |
| Details | Repeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"HEAT 11","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"HEAT 12","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 152 |
| Details | Repeat: {"description":"HEAT 13","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 204 |
| Details | Repeat: {"description":"HEAT 14","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 124 |
| Details | Repeat: {"description":"HEAT 15","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"HEAT 16","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 140 |
| Details | Repeat: {"description":"HEAT 17","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"HEAT 18","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 124 |
| Details | Repeat: {"description":"HEAT 19","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"HEAT 20","evidences":[{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 8 |
| Details | Site: {"description":"Important for interaction with cargo nuclear localization signals","evidences":[{"source":"PubMed","id":"24753571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
