2QME
Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007163 | biological_process | establishment or maintenance of cell polarity |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0008045 | biological_process | motor neuron axon guidance |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0010810 | biological_process | regulation of cell-substrate adhesion |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016601 | biological_process | Rac protein signal transduction |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030031 | biological_process | cell projection assembly |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030426 | cellular_component | growth cone |
| A | 0030865 | biological_process | cortical cytoskeleton organization |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031941 | cellular_component | filamentous actin |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0033630 | biological_process | positive regulation of cell adhesion mediated by integrin |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043020 | cellular_component | NADPH oxidase complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045730 | biological_process | respiratory burst |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071944 | cellular_component | cell periphery |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098974 | biological_process | postsynaptic actin cytoskeleton organization |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0150052 | biological_process | regulation of postsynapse assembly |
| A | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| A | 1902622 | biological_process | regulation of neutrophil migration |
| I | 0004674 | molecular_function | protein serine/threonine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 179 |
| Chain | Residue |
| A | THR17 |
| A | THR35 |
| A | GCP200 |
| A | HOH477 |
| A | HOH509 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE GCP A 200 |
| Chain | Residue |
| A | THR17 |
| A | CYS18 |
| A | PHE28 |
| A | TYR32 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | LYS116 |
| A | ASP118 |
| A | LEU119 |
| A | SER158 |
| A | ALA159 |
| A | LEU160 |
| A | MG179 |
| A | HOH303 |
| A | HOH309 |
| A | HOH319 |
| A | HOH331 |
| A | HOH338 |
| A | HOH347 |
| A | HOH359 |
| A | HOH391 |
| A | HOH477 |
| A | HOH509 |
| I | ALA27 |
| A | ALA13 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 301 |
| Chain | Residue |
| A | LYS166 |
| A | ASP170 |
| A | ARG174 |
| A | HOH489 |
| I | GLU10 |
| I | ILE11 |
| I | HOH53 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | ARG163 |
| A | GLY164 |
| A | LEU165 |
| A | LYS166 |
| A | THR167 |
| A | HOH453 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24684802","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 13 |
| Details | Domain: {"description":"CRIB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00057","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by OXSR1","evidences":[{"source":"UniProtKB","id":"P35465","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN61 |
