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2QME

Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007015biological_processactin filament organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0012505cellular_componentendomembrane system
A0014041biological_processregulation of neuron maturation
A0016055biological_processWnt signaling pathway
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019901molecular_functionprotein kinase binding
A0021894biological_processcerebral cortex GABAergic interneuron development
A0022604biological_processregulation of cell morphogenesis
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030036biological_processactin cytoskeleton organization
A0030426cellular_componentgrowth cone
A0030865biological_processcortical cytoskeleton organization
A0031175biological_processneuron projection development
A0031410cellular_componentcytoplasmic vesicle
A0031941cellular_componentfilamentous actin
A0032956biological_processregulation of actin cytoskeleton organization
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0035556biological_processintracellular signal transduction
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043020cellular_componentNADPH oxidase complex
A0043025cellular_componentneuronal cell body
A0043652biological_processengulfment of apoptotic cell
A0045730biological_processrespiratory burst
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048873biological_processhomeostasis of number of cells within a tissue
A0050885biological_processneuromuscular process controlling balance
A0050905biological_processneuromuscular process
A0051932biological_processsynaptic transmission, GABAergic
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
I0004674molecular_functionprotein serine/threonine kinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 179
ChainResidue
ATHR17
ATHR35
AGCP200
AHOH477
AHOH509

site_idAC2
Number of Residues29
DetailsBINDING SITE FOR RESIDUE GCP A 200
ChainResidue
ATHR17
ACYS18
APHE28
ATYR32
APRO34
ATHR35
AGLY60
ALYS116
AASP118
ALEU119
ASER158
AALA159
ALEU160
AMG179
AHOH303
AHOH309
AHOH319
AHOH331
AHOH338
AHOH347
AHOH359
AHOH391
AHOH477
AHOH509
IALA27
AALA13
AVAL14
AGLY15
ALYS16

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 301
ChainResidue
ALYS166
AASP170
AARG174
AHOH489
IGLU10
IILE11
IHOH53

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 302
ChainResidue
AARG163
AGLY164
ALEU165
ALYS166
ATHR167
AHOH453

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by OXSR1 => ECO:0000250|UniProtKB:P35465
ChainResidueDetails
ITHR20
AASP57
ATHR115

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24684802
ChainResidueDetails
ALYS166

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61

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PDB entries from 2024-07-24

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