Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2QKM

The crystal structure of fission yeast mRNA decapping enzyme Dcp1-Dcp2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
A	0000932	cellular_component	P-body
A	0000956	biological_process	nuclear-transcribed mRNA catabolic process
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006397	biological_process	mRNA processing
A	0008047	molecular_function	enzyme activator activity
A	0010494	cellular_component	cytoplasmic stress granule
A	0043085	biological_process	positive regulation of catalytic activity
A	0098745	cellular_component	RNA decapping complex
A	0110156	biological_process	mRNA methylguanosine-cap decapping
A	0170008	molecular_function	mRNA phosphatase activator activity
B	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
B	0003723	molecular_function	RNA binding
B	0016787	molecular_function	hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
C	0000932	cellular_component	P-body
C	0000956	biological_process	nuclear-transcribed mRNA catabolic process
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008047	molecular_function	enzyme activator activity
C	0010494	cellular_component	cytoplasmic stress granule
C	0043085	biological_process	positive regulation of catalytic activity
C	0098745	cellular_component	RNA decapping complex
C	0110156	biological_process	mRNA methylguanosine-cap decapping
C	0170008	molecular_function	mRNA phosphatase activator activity
D	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
D	0003723	molecular_function	RNA binding
D	0016787	molecular_function	hydrolase activity
D	0030145	molecular_function	manganese ion binding
D	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
E	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
E	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
E	0000932	cellular_component	P-body
E	0000956	biological_process	nuclear-transcribed mRNA catabolic process
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006397	biological_process	mRNA processing
E	0008047	molecular_function	enzyme activator activity
E	0010494	cellular_component	cytoplasmic stress granule
E	0043085	biological_process	positive regulation of catalytic activity
E	0098745	cellular_component	RNA decapping complex
E	0110156	biological_process	mRNA methylguanosine-cap decapping
E	0170008	molecular_function	mRNA phosphatase activator activity
F	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
F	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
F	0003723	molecular_function	RNA binding
F	0016787	molecular_function	hydrolase activity
F	0030145	molecular_function	manganese ion binding
F	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
G	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006397	biological_process	mRNA processing
G	0008047	molecular_function	enzyme activator activity
G	0010494	cellular_component	cytoplasmic stress granule
G	0043085	biological_process	positive regulation of catalytic activity
G	0098745	cellular_component	RNA decapping complex
G	0110156	biological_process	mRNA methylguanosine-cap decapping
G	0170008	molecular_function	mRNA phosphatase activator activity
H	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
H	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
H	0003723	molecular_function	RNA binding
H	0016787	molecular_function	hydrolase activity
H	0030145	molecular_function	manganese ion binding
H	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ATP B 267

Chain	Residue
B	SER120
B	SER121
B	GLY122
B	ARG167
B	TYR220

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ATP F 267

Chain	Residue
F	ARG167
F	GLN169
F	TYR220
F	SER120
F	SER121
F	GLY122
F	LYS129

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GkidkdEsdvdCAiREVyEEtG

Chain	Residue	Details
B	GLY128-GLY149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	133
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	242
Details	Region: {"description":"Interaction with pdc1","evidences":[{"source":"PubMed","id":"23319050","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details