2QGA
Plasmodium vivax adenylosuccinate lyase Pv003765 with AMP bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006188 | biological_process | IMP biosynthetic process |
| C | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| C | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA B 901 |
| Chain | Residue |
| B | ASN279 |
| B | ASN279 |
| B | HOH1236 |
| B | HOH1236 |
| B | HOH1244 |
| B | HOH1244 |
| B | HOH1252 |
| B | HOH1252 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA C 902 |
| Chain | Residue |
| C | ASN279 |
| C | HOH1256 |
| C | HOH1256 |
| C | HOH1258 |
| C | HOH1258 |
| C | HOH1262 |
| C | HOH1262 |
| C | ASN279 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 903 |
| Chain | Residue |
| B | ARG393 |
| B | GLN435 |
| B | HOH1071 |
| B | HOH1117 |
| B | HOH1121 |
| B | HOH1291 |
| C | LYS219 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 904 |
| Chain | Residue |
| C | ARG393 |
| C | VAL432 |
| C | GLN435 |
| C | HOH1164 |
| C | HOH1253 |
| C | HOH1324 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 905 |
| Chain | Residue |
| B | THR167 |
| B | HIS168 |
| B | SER293 |
| B | LYS299 |
| B | ASN301 |
| B | HOH1040 |
| B | HOH1053 |
| B | HOH1079 |
| C | GLN245 |
| C | AMP907 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 C 906 |
| Chain | Residue |
| B | GLN245 |
| B | AMP908 |
| C | THR167 |
| C | HIS168 |
| C | SER293 |
| C | LYS299 |
| C | ASN301 |
| C | HOH1092 |
| C | HOH1118 |
| C | HOH1255 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE AMP C 907 |
| Chain | Residue |
| B | ARG12 |
| B | TYR13 |
| B | HIS168 |
| B | ASN307 |
| B | SO4905 |
| B | HOH1281 |
| C | ASN85 |
| C | HIS86 |
| C | ASP87 |
| C | SER120 |
| C | GLU121 |
| C | GLN245 |
| C | ARG333 |
| C | SER338 |
| C | THR339 |
| C | ARG342 |
| C | HOH933 |
| C | HOH967 |
| C | HOH1007 |
| C | HOH1011 |
| C | HOH1026 |
| C | HOH1115 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE AMP B 908 |
| Chain | Residue |
| B | ASN85 |
| B | HIS86 |
| B | ASP87 |
| B | SER120 |
| B | GLU121 |
| B | GLN245 |
| B | ARG333 |
| B | SER338 |
| B | THR339 |
| B | ARG342 |
| B | HOH938 |
| B | HOH940 |
| B | HOH986 |
| B | HOH994 |
| B | HOH1011 |
| B | HOH1086 |
| C | ARG12 |
| C | TYR13 |
| C | HIS168 |
| C | ASN307 |
| C | SO4906 |
| C | HOH1313 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSstMpHKvN |
| Chain | Residue | Details |
| B | GLY292-ASN301 |
