2QG4
Crystal structure of human UDP-glucose dehydrogenase product complex with UDP-glucuronate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001702 | biological_process | gastrulation with mouth forming second |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0048666 | biological_process | neuron development |
| A | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001702 | biological_process | gastrulation with mouth forming second |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0048666 | biological_process | neuron development |
| B | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0001702 | biological_process | gastrulation with mouth forming second |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005829 | cellular_component | cytosol |
| C | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| C | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| C | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0034214 | biological_process | protein hexamerization |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0048666 | biological_process | neuron development |
| C | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0001702 | biological_process | gastrulation with mouth forming second |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005829 | cellular_component | cytosol |
| D | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| D | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| D | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0034214 | biological_process | protein hexamerization |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0048666 | biological_process | neuron development |
| D | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070062 | cellular_component | extracellular exosome |
| E | 0001702 | biological_process | gastrulation with mouth forming second |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005829 | cellular_component | cytosol |
| E | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| E | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| E | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0034214 | biological_process | protein hexamerization |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0048666 | biological_process | neuron development |
| E | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| E | 0051287 | molecular_function | NAD binding |
| E | 0070062 | cellular_component | extracellular exosome |
| F | 0001702 | biological_process | gastrulation with mouth forming second |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005829 | cellular_component | cytosol |
| F | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| F | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| F | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0034214 | biological_process | protein hexamerization |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0048666 | biological_process | neuron development |
| F | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| F | 0051287 | molecular_function | NAD binding |
| F | 0070062 | cellular_component | extracellular exosome |
| G | 0001702 | biological_process | gastrulation with mouth forming second |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0005829 | cellular_component | cytosol |
| G | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| G | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| G | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0034214 | biological_process | protein hexamerization |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0048666 | biological_process | neuron development |
| G | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| G | 0051287 | molecular_function | NAD binding |
| G | 0070062 | cellular_component | extracellular exosome |
| H | 0001702 | biological_process | gastrulation with mouth forming second |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| H | 0005634 | cellular_component | nucleus |
| H | 0005829 | cellular_component | cytosol |
| H | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| H | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| H | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0034214 | biological_process | protein hexamerization |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0048666 | biological_process | neuron development |
| H | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| H | 0051287 | molecular_function | NAD binding |
| H | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 4001 |
| Chain | Residue |
| D | MET419 |
| D | HOH4143 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 4002 |
| Chain | Residue |
| B | MET419 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL F 4003 |
| Chain | Residue |
| F | MET419 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL H 4004 |
| Chain | Residue |
| H | MET419 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 4005 |
| Chain | Residue |
| B | ASP183 |
| B | THR213 |
| B | TRP214 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 4006 |
| Chain | Residue |
| D | THR213 |
| D | ASP183 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F 4007 |
| Chain | Residue |
| F | ASP183 |
| F | THR213 |
| F | TRP214 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL H 4008 |
| Chain | Residue |
| H | ASP183 |
| H | THR213 |
| H | TRP214 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NAD A 500 |
| Chain | Residue |
| A | ILE10 |
| A | GLY11 |
| A | GLY13 |
| A | TYR14 |
| A | VAL15 |
| A | ASP36 |
| A | VAL37 |
| A | ARG41 |
| A | VAL89 |
| A | ASN90 |
| A | TYR108 |
| A | HOH563 |
| A | HOH832 |
| site_id | BC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE UGA A 501 |
| Chain | Residue |
| A | GLU161 |
| A | PHE162 |
| A | LEU163 |
| A | GLU165 |
| A | LYS220 |
| A | ASN224 |
| A | ILE231 |
| A | PHE265 |
| A | LEU266 |
| A | LYS267 |
| A | SER269 |
| A | PHE272 |
| A | GLY273 |
| A | CYS276 |
| A | PHE277 |
| A | PHE338 |
| A | LYS339 |
| A | ARG442 |
| A | HOH503 |
| A | HOH520 |
| A | HOH534 |
| A | HOH548 |
| A | HOH575 |
| A | HOH600 |
| A | HOH658 |
| A | HOH707 |
| B | ARG260 |
| site_id | BC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAD B 500 |
| Chain | Residue |
| B | ILE10 |
| B | GLY11 |
| B | GLY13 |
| B | TYR14 |
| B | VAL15 |
| B | ASP36 |
| B | VAL37 |
| B | ARG41 |
| B | SER88 |
| B | VAL89 |
| B | ASN90 |
| B | THR91 |
| B | TYR108 |
| B | SER130 |
| B | THR131 |
| B | GLU161 |
| B | LEU163 |
| B | GLU165 |
| B | CYS276 |
| B | LYS279 |
| B | ARG346 |
| B | UGA501 |
| B | HOH5012 |
| B | HOH5041 |
| B | HOH5052 |
| B | HOH5070 |
| B | HOH5079 |
| B | HOH5091 |
| B | HOH5098 |
| B | HOH5163 |
| B | HOH5179 |
| site_id | BC3 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE UGA B 501 |
| Chain | Residue |
| B | SER269 |
| B | PHE272 |
| B | GLY273 |
| B | CYS276 |
| B | PHE277 |
| B | PHE338 |
| B | LYS339 |
| B | ARG442 |
| B | NAD500 |
| B | HOH5016 |
| B | HOH5063 |
| B | HOH5070 |
| B | HOH5098 |
| B | HOH5106 |
| B | HOH5128 |
| B | HOH5130 |
| B | HOH5139 |
| A | ARG260 |
| B | GLU161 |
| B | PHE162 |
| B | LEU163 |
| B | ALA164 |
| B | GLU165 |
| B | LYS220 |
| B | ASN224 |
| B | ILE231 |
| B | PHE265 |
| B | LEU266 |
| B | LYS267 |
| site_id | BC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD C 500 |
| Chain | Residue |
| C | ILE10 |
| C | GLY11 |
| C | GLY13 |
| C | TYR14 |
| C | VAL15 |
| C | ASP36 |
| C | VAL37 |
| C | ARG41 |
| C | ILE75 |
| C | SER88 |
| C | VAL89 |
| C | ASN90 |
| C | HOH5084 |
| C | HOH5156 |
| C | HOH5206 |
| C | HOH5287 |
| site_id | BC5 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE UGA C 501 |
| Chain | Residue |
| C | GLU161 |
| C | PHE162 |
| C | LEU163 |
| C | GLU165 |
| C | LYS220 |
| C | ASN224 |
| C | ILE231 |
| C | PHE265 |
| C | LEU266 |
| C | LYS267 |
| C | SER269 |
| C | PHE272 |
| C | GLY273 |
| C | CYS276 |
| C | PHE277 |
| C | PHE338 |
| C | LYS339 |
| C | ARG442 |
| C | HOH5003 |
| C | HOH5024 |
| C | HOH5029 |
| C | HOH5039 |
| C | HOH5050 |
| C | HOH5053 |
| C | HOH5081 |
| C | HOH5094 |
| C | HOH5142 |
| D | ARG260 |
| site_id | BC6 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD D 500 |
| Chain | Residue |
| D | ILE10 |
| D | GLY11 |
| D | GLY13 |
| D | TYR14 |
| D | VAL15 |
| D | ASP36 |
| D | VAL37 |
| D | ARG41 |
| D | SER88 |
| D | VAL89 |
| D | ASN90 |
| D | THR91 |
| D | TYR108 |
| D | SER130 |
| D | THR131 |
| D | GLU161 |
| D | LEU163 |
| D | GLU165 |
| D | SER275 |
| D | CYS276 |
| D | LYS279 |
| D | ARG346 |
| D | UGA501 |
| D | HOH4055 |
| D | HOH4069 |
| D | HOH4084 |
| D | HOH4086 |
| D | HOH4109 |
| D | HOH4114 |
| D | HOH4131 |
| D | HOH4182 |
| D | HOH4352 |
| site_id | BC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE UGA D 501 |
| Chain | Residue |
| C | ARG260 |
| D | GLU161 |
| D | PHE162 |
| D | LEU163 |
| D | ALA164 |
| D | GLU165 |
| D | LYS220 |
| D | ASN224 |
| D | ILE231 |
| D | PHE265 |
| D | LEU266 |
| D | LYS267 |
| D | SER269 |
| D | PHE272 |
| D | GLY273 |
| D | CYS276 |
| D | PHE277 |
| D | PHE338 |
| D | LYS339 |
| D | ARG442 |
| D | NAD500 |
| D | HOH4059 |
| D | HOH4082 |
| D | HOH4084 |
| D | HOH4098 |
| D | HOH4114 |
| D | HOH4136 |
| D | HOH4158 |
| D | HOH4159 |
| D | HOH4189 |
| site_id | BC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NAD E 500 |
| Chain | Residue |
| E | ILE10 |
| E | GLY11 |
| E | GLY13 |
| E | TYR14 |
| E | VAL15 |
| E | ASP36 |
| E | VAL37 |
| E | ARG41 |
| E | VAL89 |
| E | ASN90 |
| E | TYR108 |
| E | HOH547 |
| E | HOH655 |
| E | HOH726 |
| E | HOH741 |
| site_id | BC9 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE UGA E 501 |
| Chain | Residue |
| E | GLU161 |
| E | PHE162 |
| E | LEU163 |
| E | GLU165 |
| E | LYS220 |
| E | ASN224 |
| E | ILE231 |
| E | PHE265 |
| E | LEU266 |
| E | LYS267 |
| E | SER269 |
| E | PHE272 |
| E | GLY273 |
| E | CYS276 |
| E | PHE277 |
| E | PHE338 |
| E | LYS339 |
| E | ARG442 |
| E | HOH502 |
| E | HOH511 |
| E | HOH532 |
| E | HOH538 |
| E | HOH543 |
| E | HOH552 |
| E | HOH631 |
| E | HOH669 |
| E | HOH725 |
| F | ARG260 |
| site_id | CC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD F 500 |
| Chain | Residue |
| F | ILE10 |
| F | GLY11 |
| F | GLY13 |
| F | TYR14 |
| F | VAL15 |
| F | ASP36 |
| F | VAL37 |
| F | ARG41 |
| F | SER88 |
| F | VAL89 |
| F | ASN90 |
| F | THR91 |
| F | TYR108 |
| F | SER130 |
| F | THR131 |
| F | GLU161 |
| F | LEU163 |
| F | GLU165 |
| F | CYS276 |
| F | LYS279 |
| F | ARG346 |
| F | UGA501 |
| F | HOH5006 |
| F | HOH5048 |
| F | HOH5081 |
| F | HOH5098 |
| F | HOH5108 |
| F | HOH5109 |
| F | HOH5173 |
| F | HOH5210 |
| F | HOH5222 |
| F | HOH5303 |
| site_id | CC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE UGA F 501 |
| Chain | Residue |
| E | ARG260 |
| F | GLU161 |
| F | PHE162 |
| F | LEU163 |
| F | ALA164 |
| F | GLU165 |
| F | LYS220 |
| F | ASN224 |
| F | ILE231 |
| F | PHE265 |
| F | LEU266 |
| F | LYS267 |
| F | SER269 |
| F | PHE272 |
| F | GLY273 |
| F | CYS276 |
| F | PHE277 |
| F | PHE338 |
| F | LYS339 |
| F | ARG442 |
| F | NAD500 |
| F | HOH5009 |
| F | HOH5076 |
| F | HOH5081 |
| F | HOH5091 |
| F | HOH5108 |
| F | HOH5117 |
| F | HOH5133 |
| F | HOH5136 |
| F | HOH5197 |
| site_id | CC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NAD G 500 |
| Chain | Residue |
| G | ILE10 |
| G | GLY11 |
| G | GLY13 |
| G | TYR14 |
| G | VAL15 |
| G | ASP36 |
| G | VAL37 |
| G | ARG41 |
| G | ILE75 |
| G | VAL89 |
| G | ASN90 |
| G | TYR108 |
| G | HOH5005 |
| G | HOH5162 |
| G | HOH5262 |
| site_id | CC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE UGA G 501 |
| Chain | Residue |
| G | GLU161 |
| G | PHE162 |
| G | LEU163 |
| G | GLU165 |
| G | LYS220 |
| G | ASN224 |
| G | ILE231 |
| G | PHE265 |
| G | LYS267 |
| G | SER269 |
| G | PHE272 |
| G | GLY273 |
| G | CYS276 |
| G | PHE277 |
| G | PHE338 |
| G | LYS339 |
| G | ARG442 |
| G | HOH5006 |
| G | HOH5026 |
| G | HOH5037 |
| G | HOH5052 |
| G | HOH5067 |
| G | HOH5094 |
| G | HOH5129 |
| H | ARG260 |
| site_id | CC5 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAD H 500 |
| Chain | Residue |
| H | ILE10 |
| H | GLY11 |
| H | GLY13 |
| H | TYR14 |
| H | VAL15 |
| H | ASP36 |
| H | VAL37 |
| H | ARG41 |
| H | SER88 |
| H | VAL89 |
| H | ASN90 |
| H | THR91 |
| H | TYR108 |
| H | ALA111 |
| H | SER130 |
| H | THR131 |
| H | GLU161 |
| H | LEU163 |
| H | GLU165 |
| H | CYS276 |
| H | LYS279 |
| H | ARG346 |
| H | UGA501 |
| H | HOH4042 |
| H | HOH4045 |
| H | HOH4090 |
| H | HOH4092 |
| H | HOH4114 |
| H | HOH4116 |
| H | HOH4139 |
| H | HOH4197 |
| H | HOH4217 |
| site_id | CC6 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE UGA H 501 |
| Chain | Residue |
| G | ARG260 |
| H | GLU161 |
| H | PHE162 |
| H | LEU163 |
| H | ALA164 |
| H | GLU165 |
| H | LYS220 |
| H | ASN224 |
| H | ILE231 |
| H | PHE265 |
| H | LEU266 |
| H | LYS267 |
| H | SER269 |
| H | PHE272 |
| H | GLY273 |
| H | CYS276 |
| H | PHE277 |
| H | PHE338 |
| H | LYS339 |
| H | ARG442 |
| H | NAD500 |
| H | HOH4011 |
| H | HOH4024 |
| H | HOH4041 |
| H | HOH4079 |
| H | HOH4092 |
| H | HOH4099 |
| H | HOH4109 |
| H | HOH4116 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 5001 |
| Chain | Residue |
| A | GLN229 |
| A | TYR299 |
| A | VAL303 |
| B | GLN229 |
| B | TYR299 |
| B | GLN302 |
| B | VAL303 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 5002 |
| Chain | Residue |
| C | GLN229 |
| C | TYR299 |
| C | VAL303 |
| D | GLN229 |
| D | TYR299 |
| D | VAL303 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO F 5003 |
| Chain | Residue |
| E | GLN229 |
| E | TYR299 |
| F | GLN229 |
| F | TYR299 |
| F | VAL303 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO G 5004 |
| Chain | Residue |
| G | GLN229 |
| G | TYR299 |
| G | VAL303 |
| H | GLN229 |
| H | TYR299 |
| H | VAL303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 176 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Region: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Region: {"description":"Important for formation of active hexamer structure","evidences":[{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 112 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 120 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| A | ASP280 | |
| A | ASN224 | |
| A | THR131 | |
| A | CYS276 | |
| A | LYS220 | |
| A | GLU165 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| B | ASP280 | |
| B | ASN224 | |
| B | THR131 | |
| B | CYS276 | |
| B | LYS220 | |
| B | GLU165 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| C | ASP280 | |
| C | ASN224 | |
| C | THR131 | |
| C | CYS276 | |
| C | LYS220 | |
| C | GLU165 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| D | ASP280 | |
| D | ASN224 | |
| D | THR131 | |
| D | CYS276 | |
| D | LYS220 | |
| D | GLU165 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| E | ASP280 | |
| E | ASN224 | |
| E | THR131 | |
| E | CYS276 | |
| E | LYS220 | |
| E | GLU165 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| F | ASP280 | |
| F | ASN224 | |
| F | THR131 | |
| F | CYS276 | |
| F | LYS220 | |
| F | GLU165 |
| site_id | CSA7 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| G | ASP280 | |
| G | ASN224 | |
| G | THR131 | |
| G | CYS276 | |
| G | LYS220 | |
| G | GLU165 |
| site_id | CSA8 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| H | ASP280 | |
| H | ASN224 | |
| H | THR131 | |
| H | CYS276 | |
| H | LYS220 | |
| H | GLU165 |
