Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2QFI

Structure of the zinc transporter YiiP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005381	molecular_function	iron ion transmembrane transporter activity
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0006826	biological_process	iron ion transport
A	0006829	biological_process	zinc ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0015086	molecular_function	cadmium ion transmembrane transporter activity
A	0015093	molecular_function	ferrous iron transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015341	molecular_function	zinc efflux active transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0034755	biological_process	iron ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070574	biological_process	cadmium ion transmembrane transport
A	0071577	biological_process	zinc ion transmembrane transport
A	0140826	molecular_function	zinc:proton antiporter activity
B	0005381	molecular_function	iron ion transmembrane transporter activity
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006812	biological_process	monoatomic cation transport
B	0006826	biological_process	iron ion transport
B	0006829	biological_process	zinc ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006882	biological_process	intracellular zinc ion homeostasis
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0015086	molecular_function	cadmium ion transmembrane transporter activity
B	0015093	molecular_function	ferrous iron transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015341	molecular_function	zinc efflux active transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0034755	biological_process	iron ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0070574	biological_process	cadmium ion transmembrane transport
B	0071577	biological_process	zinc ion transmembrane transport
B	0140826	molecular_function	zinc:proton antiporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	HIS232
B	ILE245
B	ASP285
B	VAL289

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS261
A	ASP265
A	HIS283
A	ASP285
A	ZN306

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	ALA67
A	ASP68
A	SER72
A	HIS75

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 304

Chain	Residue
B	HIS261
B	ASP265
B	HIS283
B	ASP285

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 305

Chain	Residue
B	ALA67
B	ASP68
B	SER72
B	HIS75

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 306

Chain	Residue
A	HIS232
A	ILE245
A	ASP285
A	ZN302

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 307

Chain	Residue
A	ASP45
A	ASP49
A	ASP157

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	94
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:16049012, ECO:0000269\|PubMed:19749753

Chain	Residue	Details
A	MET1-ALA16
A	VAL59-LEU81
A	TRP137-VAL147
B	MET1-ALA16
B	VAL59-LEU81
B	TRP137-VAL147

site_id	SWS_FT_FI2
Number of Residues	194
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:19749753

Chain	Residue	Details
A	THR17-ALA30
B	VAL118-ARG136
B	ARG148-VAL158
B	ASP179-GLY198
A	ALA42-LEU58
A	ALA82-GLN103
A	VAL118-ARG136
A	ARG148-VAL158
A	ASP179-GLY198
B	THR17-ALA30
B	ALA42-LEU58
B	ALA82-GLN103

site_id	SWS_FT_FI3
Number of Residues	84
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:16049012, ECO:0000269\|PubMed:19749753

Chain	Residue	Details
A	TRP31-ALA41
A	HIS104-GLY117
A	MET159-ALA178
B	TRP31-ALA41
B	HIS104-GLY117
B	MET159-ALA178

site_id	SWS_FT_FI4
Number of Residues	202
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996, ECO:0000269\|PubMed:16049012, ECO:0000269\|PubMed:19749753

Chain	Residue	Details
A	TYR199-SER300
B	TYR199-SER300

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:17717154, ECO:0000269\|PubMed:19749753, ECO:0000305\|PubMed:16790427, ECO:0007744\|PDB:2QFI, ECO:0007744\|PDB:3H90

Chain	Residue	Details
A	ASP45
A	ASP49
A	HIS153
B	ASP45
B	ASP49
B	HIS153

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:17717154, ECO:0000269\|PubMed:19749753, ECO:0007744\|PDB:2QFI, ECO:0007744\|PDB:3H90

Chain	Residue	Details
A	ASP68
A	HIS75
B	ASP68
B	HIS75

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:19749753, ECO:0007744\|PDB:3H90

Chain	Residue	Details
A	HIS71
B	HIS261
B	HIS283
B	ASP285
A	HIS232
A	HIS248
A	HIS261
A	HIS283
A	ASP285
B	HIS71
B	HIS232
B	HIS248

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:17717154, ECO:0000269\|PubMed:19749753, ECO:0000305\|PubMed:16049012, ECO:0007744\|PDB:2QFI, ECO:0007744\|PDB:3H90

Chain	Residue	Details
A	ASP157
B	ASP157

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)