2QCE

Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to sulfate, glycerol, and chloride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 481

Chain	Residue
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	GOL484
A	HOH489
A	HOH491
A	HOH520

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 482

Chain	Residue
A	LYS314

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 484

Chain	Residue
A	SER257
A	ASP259
A	LYS281
A	HIS283
A	ASP317
A	THR321
A	SO4481

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 485

Chain	Residue
A	GLY228
A	ALA229
A	GLU232
A	GLN248
A	LEU421
A	GLU422
A	ALA423
A	HOH533
A	HOH599

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Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV

Chain	Residue	Details
A	ILE309-VAL322

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For OMPdecase activity => ECO:0000269|PubMed:18184586

Chain	Residue	Details
A	ASP312
A	LYS314
A	ASP317

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD

Chain	Residue	Details
A	SER257
A	ASP317
A	THR321

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH

Chain	Residue	Details
A	ASP259
A	SER372
A	GLN430
A	GLY450

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCL

Chain	Residue	Details
A	LYS281
A	LYS314

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS314
A	ASP312

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1dbt

Chain	Residue	Details
A	LYS281
A	ASP317
A	LYS314
A	ASP312

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