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2Q98

X-ray structure of a prolactin antagonist

Functional Information from GO Data
ChainGOidnamespacecontents
A0001937biological_processnegative regulation of endothelial cell proliferation
A0005148molecular_functionprolactin receptor binding
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007166biological_processcell surface receptor signaling pathway
A0007565biological_processfemale pregnancy
A0007595biological_processlactation
A0016525biological_processnegative regulation of angiogenesis
A0030879biological_processmammary gland development
A0031667biological_processresponse to nutrient levels
A0031904cellular_componentendosome lumen
A0031982cellular_componentvesicle
A0038161biological_processprolactin signaling pathway
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A1902895biological_processpositive regulation of miRNA transcription
A1903489biological_processpositive regulation of lactation
Functional Information from PROSITE/UniProt
site_idPS00266
Number of Residues34
DetailsSOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. ChTssLaTPedkeqAqqmnqkdFlslivsIlrSW
ChainResidueDetails
ACYS58-TRP91

site_idPS00338
Number of Residues18
DetailsSOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CLRrDShKIDnYlkLlkC
ChainResidueDetails
ACYS174-CYS191

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01239
ChainResidueDetails
ASER26
ASER34
ASER90

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15687336
ChainResidueDetails
ASER135
ASER166

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine; partial
ChainResidueDetails
AASN31

227933

PDB entries from 2024-11-27

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