2Q8K

The crystal structure of Ebp1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003714	molecular_function	transcription corepressor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006364	biological_process	rRNA processing
A	0006417	biological_process	regulation of translation
A	0016020	cellular_component	membrane
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0035578	cellular_component	azurophil granule lumen
A	0043066	biological_process	negative regulation of apoptotic process
A	0045597	biological_process	positive regulation of cell differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0070062	cellular_component	extracellular exosome
A	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	ARG33
A	PRO337
A	HOH815
A	HOH847
A	HOH877
A	HOH959

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	HOH623
A	HOH678
A	HOH799
A	HOH806
A	HOH815
A	HOH890
A	HIS147
A	ARG332
A	GLY336

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	LYS191
A	VAL194
A	GLY197
A	GLU198
A	HOH729

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	ASN171
A	HIS175
A	HOH684
A	HOH754
A	HOH767
A	HOH811
A	HOH1017

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	LYS258
A	MET259
A	LYS260
A	HOH684
A	HOH743
A	HOH902

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 601

Chain	Residue
A	ILE80
A	SER81
A	VAL82
A	PHE89
A	TYR98
A	TYR309

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 602

Chain	Residue
A	PHE64
A	LYS65
A	LYS66
A	GLU67

---

Functional Information from PROSITE/UniProt

site_id	PS01202
Number of Residues	17
Details	MAP_2 Methionine aminopeptidase subfamily 2 signature. DLvKIDlGvHVDGfiaN

Chain	Residue	Details
A	ASP104-ASN120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"15064750","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCD","evidences":[{"source":"PubMed","id":"16832058","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1xgm

Chain	Residue	Details
A	ASP227

---