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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2Q7N

Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5)

Functional Information from GO Data
ChainGOidnamespacecontents
B0000902biological_processcell morphogenesis
B0001666biological_processresponse to hypoxia
B0001974biological_processblood vessel remodeling
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005146molecular_functionleukemia inhibitory factor receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0006955biological_processimmune response
B0007566biological_processembryo implantation
B0008083molecular_functiongrowth factor activity
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0010467biological_processgene expression
B0010628biological_processpositive regulation of gene expression
B0010646biological_processregulation of cell communication
B0023051biological_processregulation of signaling
B0030154biological_processcell differentiation
B0030225biological_processmacrophage differentiation
B0030324biological_processlung development
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0035019biological_processsomatic stem cell population maintenance
B0043410biological_processpositive regulation of MAPK cascade
B0045595biological_processregulation of cell differentiation
B0045651biological_processpositive regulation of macrophage differentiation
B0045835biological_processnegative regulation of meiotic nuclear division
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046697biological_processdecidualization
B0046888biological_processnegative regulation of hormone secretion
B0048144biological_processfibroblast proliferation
B0048146biological_processpositive regulation of fibroblast proliferation
B0048286biological_processlung alveolus development
B0048644biological_processmuscle organ morphogenesis
B0048666biological_processneuron development
B0048711biological_processpositive regulation of astrocyte differentiation
B0048861biological_processleukemia inhibitory factor signaling pathway
B0048863biological_processstem cell differentiation
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0051240biological_processpositive regulation of multicellular organismal process
B0060135biological_processmaternal process involved in female pregnancy
B0060426biological_processlung vasculature development
B0060463biological_processlung lobe morphogenesis
B0060707biological_processtrophoblast giant cell differentiation
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0072108biological_processpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
B0072307biological_processregulation of metanephric nephron tubule epithelial cell differentiation
B0097696biological_processcell surface receptor signaling pathway via STAT
B0140013biological_processmeiotic nuclear division
B1904894biological_processpositive regulation of receptor signaling pathway via STAT
B2000026biological_processregulation of multicellular organismal development
D0000902biological_processcell morphogenesis
D0001666biological_processresponse to hypoxia
D0001974biological_processblood vessel remodeling
D0005102molecular_functionsignaling receptor binding
D0005125molecular_functioncytokine activity
D0005146molecular_functionleukemia inhibitory factor receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005829cellular_componentcytosol
D0006955biological_processimmune response
D0007566biological_processembryo implantation
D0008083molecular_functiongrowth factor activity
D0008283biological_processcell population proliferation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0010467biological_processgene expression
D0010628biological_processpositive regulation of gene expression
D0010646biological_processregulation of cell communication
D0023051biological_processregulation of signaling
D0030154biological_processcell differentiation
D0030225biological_processmacrophage differentiation
D0030324biological_processlung development
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0033630biological_processpositive regulation of cell adhesion mediated by integrin
D0035019biological_processsomatic stem cell population maintenance
D0043410biological_processpositive regulation of MAPK cascade
D0045595biological_processregulation of cell differentiation
D0045651biological_processpositive regulation of macrophage differentiation
D0045835biological_processnegative regulation of meiotic nuclear division
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046697biological_processdecidualization
D0046888biological_processnegative regulation of hormone secretion
D0048144biological_processfibroblast proliferation
D0048146biological_processpositive regulation of fibroblast proliferation
D0048286biological_processlung alveolus development
D0048644biological_processmuscle organ morphogenesis
D0048666biological_processneuron development
D0048711biological_processpositive regulation of astrocyte differentiation
D0048861biological_processleukemia inhibitory factor signaling pathway
D0048863biological_processstem cell differentiation
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0051240biological_processpositive regulation of multicellular organismal process
D0060135biological_processmaternal process involved in female pregnancy
D0060426biological_processlung vasculature development
D0060463biological_processlung lobe morphogenesis
D0060707biological_processtrophoblast giant cell differentiation
D0070373biological_processnegative regulation of ERK1 and ERK2 cascade
D0072108biological_processpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
D0072307biological_processregulation of metanephric nephron tubule epithelial cell differentiation
D0097696biological_processcell surface receptor signaling pathway via STAT
D0140013biological_processmeiotic nuclear division
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D2000026biological_processregulation of multicellular organismal development
Functional Information from PROSITE/UniProt
site_idPS00590
Number of Residues20
DetailsLIF_OSM LIF / OSM family signature. SgkdvFQkKklgCqLLgkYK
ChainResidueDetails
BSER151-LYS170
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues198
DetailsDomain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues198
DetailsDomain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsMotif: {"description":"WSXWS motif"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues14
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17652170","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16944957","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17330941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17652170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16944957","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17652170","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8489250","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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