2PXJ

The complex structure of JMJD2A and monomethylated H3K36 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0046982	molecular_function	protein heterodimerization activity
J	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS234
A	HIS240
A	CYS306
A	CYS308

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2001

Chain	Residue
B	CYS234
B	HIS240
B	CYS306
B	CYS308

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 3001

Chain	Residue
A	GLU190
A	HIS276
A	OGA5001
A	HOH5077
A	HIS188

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 B 4001

Chain	Residue
B	HIS188
B	GLU190
B	HIS276
B	OGA6001
B	HOH6043

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OGA A 5001

Chain	Residue
A	TYR132
A	TYR177
A	PHE185
A	HIS188
A	GLU190
A	SER196
A	ASN198
A	LYS206
A	HIS276
A	SER288
A	FE23001

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OGA B 6001

Chain	Residue
B	TYR132
B	PHE185
B	HIS188
B	GLU190
B	SER196
B	ASN198
B	LYS206
B	TRP208
B	THR270
B	HIS276
B	FE24001

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16677698

Chain	Residue	Details
A	TYR132
A	ASN198
A	LYS206
B	TYR132
B	ASN198
B	LYS206

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168

Chain	Residue	Details
A	HIS188
A	HIS276
B	HIS188
B	HIS276

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168

Chain	Residue	Details
A	GLU190
B	GLU190

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I

Chain	Residue	Details
A	CYS234
A	HIS240
A	CYS306
A	CYS308
B	CYS234
B	HIS240
B	CYS306
B	CYS308

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:B2RXH2

Chain	Residue	Details
A	LYS241
B	LYS241

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2
B	ALA2

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 370

Chain	Residue	Details
A	GLY170	hydrogen bond acceptor, steric role
A	TYR177	hydrogen bond donor, steric role
A	HIS188	metal ligand
A	GLU190	attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
A	HIS276	metal ligand
A	SER288	hydrogen bond donor, steric role

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 370

Chain	Residue	Details
B	GLY170	hydrogen bond acceptor, steric role
B	TYR177	hydrogen bond donor, steric role
B	HIS188	metal ligand
B	GLU190	attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
B	HIS276	metal ligand
B	SER288	hydrogen bond donor, steric role

---