2PVS
Structure of human pancreatic lipase related protein 2 mutant N336Q
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004465 | molecular_function | lipoprotein lipase activity |
| A | 0004620 | molecular_function | phospholipase activity |
| A | 0004806 | molecular_function | triacylglycerol lipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006641 | biological_process | triglyceride metabolic process |
| A | 0008970 | molecular_function | phospholipase A1 activity |
| A | 0009395 | biological_process | phospholipid catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016298 | molecular_function | lipase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019376 | biological_process | galactolipid catabolic process |
| A | 0019433 | biological_process | triglyceride catabolic process |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0034375 | biological_process | high-density lipoprotein particle remodeling |
| A | 0034638 | biological_process | phosphatidylcholine catabolic process |
| A | 0042589 | cellular_component | zymogen granule membrane |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0044241 | biological_process | lipid digestion |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047372 | molecular_function | monoacylglycerol lipase activity |
| A | 0047714 | molecular_function | galactolipase activity |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0004465 | molecular_function | lipoprotein lipase activity |
| B | 0004620 | molecular_function | phospholipase activity |
| B | 0004806 | molecular_function | triacylglycerol lipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006641 | biological_process | triglyceride metabolic process |
| B | 0008970 | molecular_function | phospholipase A1 activity |
| B | 0009395 | biological_process | phospholipid catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016298 | molecular_function | lipase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019376 | biological_process | galactolipid catabolic process |
| B | 0019433 | biological_process | triglyceride catabolic process |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0034375 | biological_process | high-density lipoprotein particle remodeling |
| B | 0034638 | biological_process | phosphatidylcholine catabolic process |
| B | 0042589 | cellular_component | zymogen granule membrane |
| B | 0042632 | biological_process | cholesterol homeostasis |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0044241 | biological_process | lipid digestion |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047372 | molecular_function | monoacylglycerol lipase activity |
| B | 0047714 | molecular_function | galactolipase activity |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 451 |
| Chain | Residue |
| A | ARG107 |
| A | HIS108 |
| A | ARG111 |
| B | LYS80 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 452 |
| Chain | Residue |
| A | HIS108 |
| A | ARG111 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 453 |
| Chain | Residue |
| B | HIS108 |
| B | ARG111 |
| A | LYS80 |
| A | ASP83 |
| B | ARG107 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 454 |
| Chain | Residue |
| A | GLU43 |
| A | ASN44 |
| A | PRO45 |
| A | ASN46 |
| A | ASN47 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 455 |
| Chain | Residue |
| A | PHE314 |
| A | GLY316 |
| A | LYS317 |
| A | THR318 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 502 |
| Chain | Residue |
| A | GLU187 |
| A | ARG190 |
| A | ASP192 |
| A | ASP195 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 451 |
| Chain | Residue |
| B | HIS108 |
| B | ARG111 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 452 |
| Chain | Residue |
| B | ASN44 |
| B | PRO45 |
| B | ASN46 |
| B | ASN47 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 453 |
| Chain | Residue |
| B | LYS315 |
| B | GLY316 |
| B | LYS317 |
| B | THR318 |
| B | SER319 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 501 |
| Chain | Residue |
| B | GLU187 |
| B | ARG190 |
| B | ASP192 |
| B | ASP195 |
| B | HOH511 |
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. VHVIGHSLGA |
| Chain | Residue | Details |
| A | VAL146-ALA155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Required for galactolipase activity","evidences":[{"source":"PubMed","id":"26494624","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10037","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18702514","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OXE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 112 |
| Details | Domain: {"description":"PLAT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00152","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
