2PSW

Human MAK3 homolog in complex with CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004596	molecular_function	peptide alpha-N-acetyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006474	biological_process	N-terminal protein amino acid acetylation
A	0007064	biological_process	mitotic sister chromatid cohesion
A	0010485	molecular_function	histone H4 acetyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0031415	cellular_component	NatA complex
A	0034087	biological_process	establishment of mitotic sister chromatid cohesion
A	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	0071962	biological_process	mitotic sister chromatid cohesion, centromeric
A	0120518	molecular_function	peptide-methionine-alpha-N-acetyltransferase activity
B	0004596	molecular_function	peptide alpha-N-acetyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006474	biological_process	N-terminal protein amino acid acetylation
B	0007064	biological_process	mitotic sister chromatid cohesion
B	0010485	molecular_function	histone H4 acetyltransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0031415	cellular_component	NatA complex
B	0034087	biological_process	establishment of mitotic sister chromatid cohesion
B	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
B	0070062	cellular_component	extracellular exosome
B	0071962	biological_process	mitotic sister chromatid cohesion, centromeric
B	0120518	molecular_function	peptide-methionine-alpha-N-acetyltransferase activity
C	0004596	molecular_function	peptide alpha-N-acetyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006338	biological_process	chromatin remodeling
C	0006474	biological_process	N-terminal protein amino acid acetylation
C	0007064	biological_process	mitotic sister chromatid cohesion
C	0010485	molecular_function	histone H4 acetyltransferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0031415	cellular_component	NatA complex
C	0034087	biological_process	establishment of mitotic sister chromatid cohesion
C	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
C	0070062	cellular_component	extracellular exosome
C	0071962	biological_process	mitotic sister chromatid cohesion, centromeric
C	0120518	molecular_function	peptide-methionine-alpha-N-acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE COA A 201

Chain	Residue
A	PHE27
A	GLY89
A	THR90
A	ASN117
A	SER119
A	ASP122
A	PHE123
A	TYR124
A	LYS126
A	HOH203
A	HOH226
A	LEU77
A	HOH243
A	HOH244
A	HOH248
A	GLY78
A	CYS79
A	ARG84
A	ARG85
A	LEU86
A	GLY87
A	ILE88

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE COA B 201

Chain	Residue
B	ILE26
B	PHE27
B	LEU77
B	GLY78
B	CYS79
B	ARG84
B	ARG85
B	LEU86
B	GLY87
B	ILE88
B	GLY89
B	THR90
B	ASN117
B	SER119
B	ALA120
B	ASP122
B	PHE123
B	TYR124
B	LYS126
B	HOH202
B	HOH203
B	HOH228
B	HOH230
B	HOH233
B	HOH240
B	HOH241

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE COA C 201

Chain	Residue
C	ILE26
C	PHE27
C	LEU77
C	GLY78
C	CYS79
C	ARG84
C	ARG85
C	LEU86
C	GLY87
C	ILE88
C	GLY89
C	THR90
C	LEU111
C	ASN117
C	SER119
C	ASP122
C	PHE123
C	TYR124
C	LYS126
C	HOH202
C	HOH236
C	HOH248
C	HOH255
C	HOH258

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:21900231

Chain	Residue	Details
A	TYR73
A	HIS112
B	TYR73
B	HIS112
C	TYR73
C	HIS112

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:27484799, ECO:0007744|PDB:3TFY, ECO:0007744|PDB:4X5K

Chain	Residue	Details
A	TYR31
A	MSE75
A	TYR138
B	TYR31
B	MSE75
B	TYR138
C	TYR31
C	MSE75
C	TYR138

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21900231, ECO:0000269|PubMed:27484799, ECO:0000269|Ref.19, ECO:0007744|PDB:2PSW, ECO:0007744|PDB:3TFY, ECO:0007744|PDB:4X5K

Chain	Residue	Details
A	LEU77
A	ASN117
B	LEU77
B	ASN117
C	LEU77
C	ASN117

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR12
B	THR12
C	THR12

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:19744929, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS34
A	LYS37
B	LYS34
B	LYS37
C	LYS34
C	LYS37

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
A	TYR110
B	TYR110
C	TYR110

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:19744929

Chain	Residue	Details
A	LYS140
B	LYS140
C	LYS140

---