2PQF

Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment in complex with an inhibitor 3-Aminobenzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
B	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
D	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
E	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
F	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GAB A 701

Chain	Residue
A	HIS564
A	GLY565
A	TYR596
A	PHE597
A	ALA598
A	TYR603
A	SER604
A	TYR607
A	ILE660

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT A 801

Chain	Residue
A	HOH121
A	HOH193
A	HOH302
A	HIS564
A	THR566
A	PHE570
A	ILE574
A	ASP580
A	CYS584

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GAB B 701

Chain	Residue
B	HIS564
B	GLY565
B	TYR596
B	PHE597
B	ALA598
B	TYR603
B	SER604
B	TYR607
B	ILE660

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT B 801

Chain	Residue
B	HOH141
B	HOH307
B	HIS564
B	THR566
B	PHE570
B	ILE574
B	PHE579
B	ASP580
B	CYS584

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GAB C 701

Chain	Residue
C	HOH145
C	HIS564
C	GLY565
C	TYR596
C	PHE597
C	ALA598
C	TYR603
C	SER604
C	TYR607
C	ILE660

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CIT C 801

Chain	Residue
C	HOH96
C	HOH134
C	HOH207
C	HOH314
C	HIS564
C	THR566
C	PHE570
C	ILE574
C	PHE579
C	ASP580
C	VAL583
C	CYS584

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GAB D 701

Chain	Residue
D	HIS564
D	GLY565
D	TYR596
D	PHE597
D	ALA598
D	TYR603
D	SER604
D	TYR607
D	ILE660

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT D 801

Chain	Residue
D	HOH251
D	HIS564
D	THR566
D	PHE570
D	ILE574
D	ASP580
D	VAL583

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GAB E 701

Chain	Residue
E	HIS564
E	GLY565
E	TYR596
E	PHE597
E	ALA598
E	TYR603
E	SER604
E	TYR607
E	ILE660

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT E 801

Chain	Residue
E	HIS564
E	THR566
E	PHE570
E	ILE574
E	ASP580
E	VAL583

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GAB F 701

Chain	Residue
F	HIS564
F	GLY565
F	TYR596
F	PHE597
F	ALA598
F	TYR603
F	SER604
F	TYR607
F	ILE660

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT F 801

Chain	Residue
F	GLY565
F	THR566
F	PHE570
F	ASP580
F	VAL583
F	HIS564

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: ADP-ribosyl aspartic acid => ECO:0000269|PubMed:25043379

Chain	Residue	Details
A	ASP600
E	ASP611
F	ASP600
F	ASP611
A	ASP611
B	ASP600
B	ASP611
C	ASP600
C	ASP611
D	ASP600
D	ASP611
E	ASP600

---