2PQA

Crystal Structure of Full-length Human RPA 14/32 Heterodimer

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005662	cellular_component	DNA replication factor A complex
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0007346	biological_process	regulation of mitotic cell cycle
B	0035861	cellular_component	site of double-strand break
B	0042127	biological_process	regulation of cell population proliferation
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005662	cellular_component	DNA replication factor A complex
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006289	biological_process	nucleotide-excision repair
D	0006298	biological_process	mismatch repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0007346	biological_process	regulation of mitotic cell cycle
D	0035861	cellular_component	site of double-strand break
D	0042127	biological_process	regulation of cell population proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	DNA binding: {"description":"OB"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"26474068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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