2PPB

Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0006351	biological_process	DNA-templated transcription
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0006351	biological_process	DNA-templated transcription
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0034062	molecular_function	5'-3' RNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0034062	molecular_function	5'-3' RNA polymerase activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0006351	biological_process	DNA-templated transcription
K	0034062	molecular_function	5'-3' RNA polymerase activity
K	0046983	molecular_function	protein dimerization activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0006351	biological_process	DNA-templated transcription
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0046983	molecular_function	protein dimerization activity
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed RNA polymerase activity
M	0006351	biological_process	DNA-templated transcription
M	0032549	molecular_function	ribonucleoside binding
M	0034062	molecular_function	5'-3' RNA polymerase activity
N	0000287	molecular_function	magnesium ion binding
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed RNA polymerase activity
N	0005515	molecular_function	protein binding
N	0006351	biological_process	DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0034062	molecular_function	5'-3' RNA polymerase activity
O	0003677	molecular_function	DNA binding
O	0003899	molecular_function	DNA-directed RNA polymerase activity
O	0006351	biological_process	DNA-templated transcription
O	0034062	molecular_function	5'-3' RNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE STD D 7001

Chain	Residue
C	ARG422
D	PRO1257
D	HOH9308
I	DG5
C	ARG428
C	ALA447
C	ILE449
D	ALA1082
D	ALA1085
D	LEU1086
D	ARG1087
D	ASP1090

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE STD N 8001

Chain	Residue
M	ARG422
M	PHE425
M	ALA447
M	ILE449
N	ALA1082
N	ALA1085
N	LEU1086
N	ARG1087
N	ASP1090
N	PRO1257
N	HOH9065
Z	DG5

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 7058

Chain	Residue
D	CYS58
D	CYS60
D	CYS73
D	CYS76

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 8112

Chain	Residue
D	CYS1112
D	CYS1194
D	CYS1201
D	CYS1204

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 7158

Chain	Residue
N	CYS58
N	CYS60
N	CYS73
N	CYS76

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 8212

Chain	Residue
N	CYS1112
N	CYS1194
N	CYS1201
N	CYS1204

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 9001

Chain	Residue
D	ASP739
D	ASP741
D	ASP743
H	G16

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 9002

Chain	Residue
D	ASP739
D	APC5999
D	HOH9004

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG N 9003

Chain	Residue
N	ASP739
N	ASP741
N	ASP743
Y	G16

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG N 9004

Chain	Residue
M	APC6999
M	HOH7001
N	ASP739

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE APC D 5999

Chain	Residue
C	ARG557
C	ARG879
D	ARG704
D	PRO706
D	ASN737
D	ARG1029
D	MG9002
D	HOH9003
D	HOH9004
D	HOH9231
D	HOH9347
D	HOH9498
G	DT14
H	G16

---

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE APC M 6999

Chain	Residue
M	ARG557
M	ARG879
M	HOH7000
M	HOH7319
N	ARG704
N	PRO706
N	ASN737
N	ARG1029
N	MG9004
X	DT14
Y	G16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	912
Details	Region: {"description":"Alpha N-terminal domain (alpha-NTD)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---