2PMW
The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLN101 |
| A | ARG104 |
| A | ARG105 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | GLN90 |
| A | ARG93 |
| A | HIS139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 |
| Chain | Residue | Details |
| B | ASP186 | |
| B | HIS226 | |
| B | SER386 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035 |
| Chain | Residue | Details |
| B | ARG218 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER688 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035 |
| Chain | Residue | Details |
| B | ASN533 |
