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2PKG

Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0000775cellular_componentchromosome, centromeric region
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007059biological_processchromosome segregation
A0007143biological_processfemale meiotic nuclear division
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016328cellular_componentlateral plasma membrane
A0019888molecular_functionprotein phosphatase regulator activity
A0030425cellular_componentdendrite
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0040008biological_processregulation of growth
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0045202cellular_componentsynapse
A0045595biological_processregulation of cell differentiation
A0046982molecular_functionprotein heterodimerization activity
A0051232biological_processmeiotic spindle elongation
A0051306biological_processmitotic sister chromatid separation
A0051754biological_processmeiotic sister chromatid cohesion, centromeric
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0090443cellular_componentFAR/SIN/STRIPAK complex
A0098978cellular_componentglutamatergic synapse
A1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
A1990405molecular_functionprotein antigen binding
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000159cellular_componentprotein phosphatase type 2A complex
B0000775cellular_componentchromosome, centromeric region
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007059biological_processchromosome segregation
B0007143biological_processfemale meiotic nuclear division
B0015630cellular_componentmicrotubule cytoskeleton
B0016020cellular_componentmembrane
B0016328cellular_componentlateral plasma membrane
B0019888molecular_functionprotein phosphatase regulator activity
B0030425cellular_componentdendrite
B0035331biological_processnegative regulation of hippo signaling
B0035556biological_processintracellular signal transduction
B0040008biological_processregulation of growth
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043029biological_processT cell homeostasis
B0045202cellular_componentsynapse
B0045595biological_processregulation of cell differentiation
B0046982molecular_functionprotein heterodimerization activity
B0051232biological_processmeiotic spindle elongation
B0051306biological_processmitotic sister chromatid separation
B0051754biological_processmeiotic sister chromatid cohesion, centromeric
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0065003biological_processprotein-containing complex assembly
B0070062cellular_componentextracellular exosome
B0090443cellular_componentFAR/SIN/STRIPAK complex
B0098978cellular_componentglutamatergic synapse
B1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
B1990405molecular_functionprotein antigen binding
B2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN C 175
ChainResidue
CCYS103
CSER108
CCYS111
CCYS113
CCYS116

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 176
ChainResidue
CHIS122
CCYS138
CCYS140
CCYS143

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 175
ChainResidue
DCYS103
DCYS111
DCYS113
DCYS116

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 176
ChainResidue
DHIS122
DCYS138
DCYS140
DCYS143

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsZN_FING: C4-type; atypical
ChainResidueDetails
CCYS103-CYS116
DCYS103-CYS116

site_idSWS_FT_FI2
Number of Residues42
DetailsZN_FING: H1C3-type; atypical
ChainResidueDetails
CHIS122-CYS143
DHIS122-CYS143

226707

PDB entries from 2024-10-30

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